{"id":"W4412573084","doi":"10.1186/s13550-025-01279-7","title":"Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain","year":2025,"lang":"en","type":"article","venue":"EJNMMI Research","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Eidgenössische Technische Hochschule Zürich","keywords":"Medicine; Tyrosine; Kinetics; Amino acid; Cardiac imaging; Human brain; Pharmacology; TRACER; Cancer research; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008406104,0.0001534049,0.0002148327,0.0001671972,0.0001102027,0.00002615176,0.0006513529,0.0001923896,0.00006629356],"category_scores_gemma":[0.000449654,0.0001183001,0.0001215161,0.0006051621,0.0003933623,0.00000396413,0.0004949931,0.000416546,0.000006564365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002903537,"about_ca_system_score_gemma":0.0001009643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009667059,"about_ca_topic_score_gemma":0.0003311655,"domain_scores_codex":[0.998109,0.0002930299,0.0003180785,0.0003832303,0.000393941,0.0005027094],"domain_scores_gemma":[0.9988371,0.00004432325,0.00005365239,0.0007906723,0.0002084535,0.00006583444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004057472,0.0001346147,0.001946259,0.00004062014,0.00002140161,0.000002740232,0.00008428719,0.00001661883,0.9611261,0.002584428,0.03011184,0.003890465],"study_design_scores_gemma":[0.0005678119,0.0001069726,0.05736422,0.00003471138,0.000005419189,0.000001681972,0.0001299728,0.00001002991,0.7202072,0.0002201904,0.2212673,0.00008451224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793219,0.004671209,0.0001316763,0.002812169,0.0002019399,0.0004079243,0.00002415932,0.000007253922,0.01242176],"genre_scores_gemma":[0.974786,0.0002177078,0.0001756328,0.0002952988,0.0001628281,0.00003527608,0.00003081511,0.00002113694,0.02427532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2409189,"threshold_uncertainty_score":0.4824137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02989395409028557,"score_gpt":0.3626368066178708,"score_spread":0.3327428525275853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}