{"id":"W4412583733","doi":"10.3389/fcell.2025.1642006","title":"Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts","year":2025,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Cancer research; Cell culture; Burkitt's lymphoma; Glutathione; RNA Helicase A; Lymphoma; Buthionine sulfoximine; Biology; Chemistry; Molecular biology; Helicase; Enzyme; Biochemistry; Gene; Immunology; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914505,0.0003435716,0.0002582887,0.0002021424,0.0001493645,0.0002517764,0.0001912664,0.0002709861,0.001561525],"category_scores_gemma":[0.00008044569,0.0001468149,0.0001626413,0.0001650491,0.0001704472,0.0001707394,0.0001385412,0.0007220976,0.0003708724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540043,"about_ca_system_score_gemma":0.0002273655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183407,"about_ca_topic_score_gemma":0.001931392,"domain_scores_codex":[0.9998404,0.00003117182,0.0000196076,0.00002907132,0.0000414628,0.00003823865],"domain_scores_gemma":[0.999915,0.00002302795,0.00001840687,0.00001162452,0.000008537815,0.00002339652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007516395,0.00005525096,0.0001024181,0.00002141039,0.000003267493,0.00001356706,0.00001007502,0.00006550422,0.9989937,0.00003819501,0.00003648655,0.0005850054],"study_design_scores_gemma":[0.00002863895,0.0008073169,0.001558636,0.000003401726,0.000009382592,0.00009536197,0.00002097421,0.001133487,0.9948539,0.00002507282,0.001461252,0.000002641386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944819,0.00114436,0.002159492,0.0001118721,0.00002770941,0.00006017863,0.0006306657,0.000157763,0.001226009],"genre_scores_gemma":[0.9927249,0.0006677722,0.002460748,0.00003788568,0.000005052036,0.00006742166,0.0007794,0.00002387618,0.003232824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561525,"threshold_uncertainty_score":0.005223811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006964480076060702,"score_gpt":0.2637099387843543,"score_spread":0.2567454587082936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}