{"id":"W4412588977","doi":"10.1038/s41582-025-01115-5","title":"Advancing multiple sclerosis management in older adults","year":2025,"lang":"en","type":"review","venue":"Nature Reviews Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Calgary; St. Michael's Hospital; Queen's University; University of Manitoba; Dalhousie University","funders":"Janssen Pharmaceuticals; EMD Serono; Medical Research Council; Teva Pharmaceutical Industries; Neuraxpharm; National Health and Medical Research Council; Pfizer Foundation; Crohn's and Colitis Canada; Sanofi; Multiple Sclerosis International Federation; Celltrion; Eisai; Arthritis Society; Mylan; TG Therapeutics; Multiple Sclerosis Australia; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; Pfizer; Biogen; Celgene; Canadian Institutes of Health Research; Prothena; Alexion Pharmaceuticals; U.S. Department of Defense; Eli Lilly and Company; Samsung; Bristol-Myers Squibb; MedDay Pharmaceuticals; Genentech; National Multiple Sclerosis Society","keywords":"Medicine; Multiple sclerosis; MEDLINE; Physical medicine and rehabilitation; Intensive care medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002786422,0.001203089,0.003843588,0.003762939,0.0002736841,0.001495744,0.001061093,0.001672696,0.005417596],"category_scores_gemma":[0.006653657,0.0004060258,0.002078867,0.003312012,0.0004114004,0.001504541,0.00120783,0.001619673,0.0007551343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00115958,"about_ca_system_score_gemma":0.00280597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004211531,"about_ca_topic_score_gemma":0.01118946,"domain_scores_codex":[0.998944,0.0003121999,0.0003322758,0.0001095162,0.0002418725,0.00006017221],"domain_scores_gemma":[0.9965696,0.002353635,0.000591594,0.00003763818,0.00034631,0.0001011813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003224312,0.00006505674,0.0005408833,0.267573,0.00198328,0.0001180206,0.00009404001,0.0001533427,0.0003257694,0.0006838968,0.01663912,0.7115011],"study_design_scores_gemma":[0.0009551612,0.0005766273,0.009154932,0.4882555,0.02119629,0.001130809,0.0003959431,0.0001738891,0.0003531393,0.002378436,0.4753387,0.00009060341],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004144172,0.9996438,0.0000142799,0.00009976522,0.0000936124,0.000004477627,0.00001155769,0.000001464631,0.00008964722],"genre_scores_gemma":[0.0005099873,0.9989536,0.00007350185,0.0002934576,0.00009310133,0.00000910068,0.00001636606,4.53221e-7,0.00005051357],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005417596,"threshold_uncertainty_score":0.01812363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05286263344797532,"score_gpt":0.380325344693807,"score_spread":0.3274627112458317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}