{"id":"W4412596159","doi":"10.1128/aac.00427-25","title":"Osh2 mediates <i>Candida</i> species resistance to miltefosine by regulating zymosterol accumulation","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Biology; Miltefosine; Ergosterol; Microbiology; Drug resistance; Candida glabrata; Candida albicans; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003559,0.0004923018,0.0002640804,0.0001874688,0.0002192043,0.0005721367,0.000292235,0.0003555816,0.001866677],"category_scores_gemma":[0.000113127,0.0001463252,0.0003456054,0.0001471384,0.0002761447,0.0001656299,0.0004384224,0.0005282812,0.000707667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603646,"about_ca_system_score_gemma":0.0002673403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127519,"about_ca_topic_score_gemma":0.001282492,"domain_scores_codex":[0.9998783,0.000008203821,0.000009093749,0.0000330142,0.00003484143,0.00003665592],"domain_scores_gemma":[0.9999037,0.000008441301,0.00003419396,0.00001033353,0.00001406798,0.00002927326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001152831,0.00001338016,0.0008106356,0.00006056743,0.000006935813,0.00006503032,0.00001096388,0.00008066917,0.9975023,0.0001258805,0.0002087293,0.0009997115],"study_design_scores_gemma":[0.00002949132,0.000133898,0.02844723,0.0000242816,0.00003648766,0.0003544807,0.0001170103,0.002625701,0.9605659,0.000168926,0.00747835,0.0000182205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847834,0.002336693,0.004436167,0.000362964,0.0001239549,0.00004479218,0.003727702,0.0006052605,0.003579051],"genre_scores_gemma":[0.9936385,0.0005593116,0.0009828327,0.0001422257,0.00001475284,0.00002124295,0.002249772,0.00005865267,0.002332686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866677,"threshold_uncertainty_score":0.0062446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666207587808905,"score_gpt":0.294493065957132,"score_spread":0.277830990079043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}