{"id":"W4412599437","doi":"10.1016/j.bpsc.2025.07.005","title":"Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Posttraumatic Stress Disorder Research","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Child Health and Human Development; National Institute of Mental Health; Institute of Psychology, Chinese Academy of Sciences; National Social Science Fund of China; Medical Research Council; National Science Foundation; Clinical Science Research and Development; Chugai Pharmaceutical; Dana Foundation; H. Lundbeck A/S; National Institutes of Health; American Psychological Association; U.S. Department of Defense; People’s Liberation Army Navy General Hospital; Fonds Spéciaux de Recherche; Fondation Pierre Deniker pour la Recherche et la Prévention en Santé Mentale; Universiteit Gent; Bijzonder Onderzoeksfonds UGent; Ministerstvo Zdravotnictví Ceské Republiky; Ministry of Education; Academisch Medisch Centrum; Natural Science Foundation of Jiangsu Province; ZonMw; Ministry of Education of the People's Republic of China; International Society for the Study of Trauma and Dissociation; Chinese Academy of Sciences; Deutsche Forschungsgemeinschaft; National Center for PTSD, U.S. Department of Veterans Affairs; Arrowhead Pharmaceuticals; Institute for Clinical and Translational Research, University of Wisconsin, Madison; Sage Therapeutics; McLean Hospital; Ministerstvo Školství, Mládeže a Tělovýchovy; Genentech; ACADIA Pharmaceuticals; Congressionally Directed Medical Research Programs; BIRD Foundation; Michael J. Fox Foundation for Parkinson's Research; Jazz Pharmaceuticals; Waisman Center; National Alliance for Research on Schizophrenia and Depression; Neurocrine Biosciences; Government of Jiangsu Province; Vanderbilt University; Eisai; National Natural Science Foundation of China; U.S. Department of Veterans Affairs; Office of Research and Development; Rehabilitation Research and Development Service; Brain and Behavior Research Foundation; South African Medical Research Council; Takeda Oncology","keywords":"Workgroup; Mega-; Psychology; Clinical psychology; Computer science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001599243,0.000634914,0.000672941,0.0008071182,0.0008327207,0.0007175239,0.0008701854,0.0004424668,0.006353535],"category_scores_gemma":[0.003165646,0.0004582033,0.002202009,0.0009265626,0.000442558,0.0004624285,0.001496795,0.0008203821,0.0005802101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993524,"about_ca_system_score_gemma":0.0003731948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005838203,"about_ca_topic_score_gemma":0.005770986,"domain_scores_codex":[0.9991486,0.0003296421,0.00004385719,0.0002539101,0.00008900256,0.0001350618],"domain_scores_gemma":[0.9981257,0.0007409436,0.0003420437,0.0003749577,0.0001908798,0.0002254503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002667434,0.0001246023,0.9625434,0.000130209,0.01303475,0.0004323397,0.0006974429,0.0003946982,0.005067508,0.0003664736,0.002465092,0.01207608],"study_design_scores_gemma":[0.00005904011,0.000178351,0.9954934,0.00002181934,0.001817102,0.0004028846,0.0003713495,0.0005248386,0.0002759316,0.000271839,0.0005710144,0.00001232182],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971048,0.0004810458,0.0008868391,0.0001581608,0.00001719816,0.00001321585,0.001002877,0.00001260357,0.0003232166],"genre_scores_gemma":[0.997823,0.000134017,0.0004811797,0.0000451429,0.00002218635,0.00002510779,0.001009396,0.00005025231,0.000409631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006353535,"threshold_uncertainty_score":0.02125466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0670033520798026,"score_gpt":0.3631830262406623,"score_spread":0.2961796741608597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}