{"id":"W4412603160","doi":"10.1016/j.ijrobp.2025.07.1425","title":"Phase 3 Trial of Dose-Escalated Radiation Therapy and Standard Androgen Deprivation Therapy Versus Dose-Escalated Radiation Therapy and Enhanced Androgen Deprivation Therapy With Orteronel for Men With High-Risk Prostate Cancer (NRG/RTOG 1115)","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Interior Health","funders":"Astellas Pharma; NRG Oncology; National Cancer Institute; Boston Scientific Corporation; Genentech; American College of Radiation Oncology; Celgene; AstraZeneca; Takeda Pharmaceuticals U.S.A.; Pfizer","keywords":"Androgen deprivation therapy; Prostate cancer; Medicine; Radiation therapy; Oncology; Internal medicine; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002522581,0.002471641,0.003377358,0.0006581562,0.0005431336,0.001599897,0.001876824,0.001733861,0.01170686],"category_scores_gemma":[0.001722849,0.0008274395,0.003423994,0.0006024136,0.002083999,0.001393784,0.0006679841,0.006017361,0.001560055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00189155,"about_ca_system_score_gemma":0.002402743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003393023,"about_ca_topic_score_gemma":0.008102156,"domain_scores_codex":[0.999118,0.0004356137,0.00002959765,0.000188162,0.00005718397,0.0001713187],"domain_scores_gemma":[0.9986355,0.0003458778,0.0002643907,0.0001359112,0.0000543617,0.000563971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9718858,0.01096161,0.0003742689,0.0001833166,0.0008394854,0.00001802484,0.0000733075,0.001058893,0.002361023,0.0001835963,0.001012934,0.01104761],"study_design_scores_gemma":[0.8836637,0.1117548,0.001967186,0.00002036104,0.0003559719,0.00003009156,0.00003950454,0.0007297434,0.000443153,0.0003078715,0.0006649159,0.0000226743],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863837,0.002021533,0.0009585833,0.001053522,0.0005101846,0.002815072,0.002557324,0.0002514556,0.003448544],"genre_scores_gemma":[0.9770125,0.001518509,0.003594603,0.002022926,0.0004289345,0.004638256,0.003566902,0.0001036636,0.007113524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01170686,"threshold_uncertainty_score":0.03916335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02857638083174456,"score_gpt":0.3626273983218109,"score_spread":0.3340510174900663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}