{"id":"W4412611761","doi":"10.1016/j.cgh.2025.06.036","title":"FIB-4-based Referral Pathways Have Suboptimal Accuracy to Identify Increased Liver Stiffness and Incident Advanced Liver Disease","year":2025,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Stichting voor Lever- en Maag-Darm Onderzoek","keywords":"Medicine; Liver disease; Referral; Disease; Transient elastography; Internal medicine; Liver biopsy; Family medicine; Biopsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01390673,0.0008099442,0.0007302281,0.001686113,0.0005514504,0.002065999,0.001602998,0.001364721,0.002033111],"category_scores_gemma":[0.04044529,0.0005087199,0.001128686,0.001428219,0.0004957011,0.001315658,0.001347791,0.0007999177,0.001044336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009319973,"about_ca_system_score_gemma":0.001192849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007720718,"about_ca_topic_score_gemma":0.01383768,"domain_scores_codex":[0.9900914,0.005644626,0.001016498,0.001168472,0.001379326,0.000699752],"domain_scores_gemma":[0.9788745,0.00982594,0.005082117,0.001526995,0.003861795,0.000828638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002632471,0.0000347672,0.9922001,0.00005596544,0.0001534861,0.00002356373,0.00009324447,0.0002555287,0.0001419277,0.00005221321,0.0004520692,0.006274022],"study_design_scores_gemma":[0.00005516428,0.0003548121,0.9886343,0.0002146438,0.0002609251,0.0005076033,0.0003936181,0.007512569,0.0005063776,0.0004232576,0.001112626,0.00002390923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917837,0.002197083,0.001685941,0.0007338205,0.00007733482,0.00008285855,0.001036788,0.00008316636,0.002319356],"genre_scores_gemma":[0.9967796,0.0002428316,0.001804085,0.0002537208,0.00003011321,0.00003809103,0.000620277,0.000009854884,0.0002214966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01390673,"threshold_uncertainty_score":0.07354671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04904450617012151,"score_gpt":0.3776334520898796,"score_spread":0.3285889459197581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}