{"id":"W4412630273","doi":"10.1002/eji.70009","title":"LAG3 Marks Activated but Hyporesponsive NK Cells","year":2025,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Ottawa Hospital; Alberta Cancer Foundation; Institute of Infection and Immunity; University of Ottawa","funders":"Cumming School of Medicine, University of Calgary; Cancer Council NSW; Horizon 2020 Framework Programme; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Canada Foundation for Innovation; Social Sciences and Humanities Research Council of Canada; Melanoma Research Alliance; University of Toronto; University of Ottawa; Canadian Cancer Society; Alberta Cancer Foundation; National Institute of Allergy and Infectious Diseases; Cancer Research Society; Canadian Allergy, Asthma and Immunology Foundation; Ottawa Hospital Research Institute; H2020 Marie Skłodowska-Curie Actions; University of Pittsburgh","keywords":"Biology; Interleukin 21; TIGIT; Interleukin 12; Immune system; Immunology; Cytotoxic T cell; Cancer research; Immune checkpoint; IL-2 receptor; ZAP70; NK-92; Immunosurveillance; CD8; Cell biology; T cell; Immunotherapy; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008601853,0.0002010849,0.0001297598,0.0002683925,0.0001662007,0.0003804042,0.00009609572,0.0002623451,0.002031564],"category_scores_gemma":[0.00009974325,0.00007357134,0.0001584104,0.000146193,0.0002246677,0.0002077935,0.0002401061,0.0004323011,0.000599633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005631,"about_ca_system_score_gemma":0.0001445691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002524042,"about_ca_topic_score_gemma":0.0003808859,"domain_scores_codex":[0.9998904,0.00001330808,0.00001107784,0.00002529604,0.00001688789,0.00004296854],"domain_scores_gemma":[0.9999115,0.00001385784,0.00002568974,0.0000143943,0.000008675866,0.00002577075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001138195,0.000005762654,0.0008541557,0.00001806953,0.00000170886,0.00009577779,0.00001887315,0.00002024205,0.9980691,0.00007701813,0.0000179258,0.0007076559],"study_design_scores_gemma":[0.00002628624,0.0003708204,0.06587621,0.0000267066,0.00002292304,0.002264243,0.0002905403,0.0008162846,0.9247712,0.0003869873,0.005136995,0.00001080702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939176,0.001283712,0.003037839,0.00004708637,0.00002055874,0.00001388958,0.0004680027,0.00006787255,0.001143351],"genre_scores_gemma":[0.99732,0.0002803965,0.0009047403,0.00003995601,0.000008017218,0.00001485897,0.0003646362,0.00001344179,0.001053947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002031564,"threshold_uncertainty_score":0.006796241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007215037875944224,"score_gpt":0.2127360157382619,"score_spread":0.2055209778623177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}