{"id":"W4412635154","doi":"10.3390/vaccines13080788","title":"Comparative Analysis of Chitosan, Lipid Nanoparticles, and Alum Adjuvants in Recombinant SARS-CoV-2 Vaccine: An Evaluation of Their Immunogenicity and Serological Efficacy","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Mitacs; University of Pennsylvania","keywords":"Adjuvant; Immune system; Immunogenicity; Alum; Glucosamine; Immunogen; Eotaxin; Cytokine; Chitosan; Immunology; Antibody; Splenocyte; Chemokine; Chemistry; Pharmacology; Biology; Biochemistry; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009235829,0.0001826826,0.0009164074,0.0006324458,0.0000487681,0.0000143865,0.0001315684,0.0001135663,0.000005257195],"category_scores_gemma":[0.0002987668,0.0001319847,0.00009440487,0.001523887,0.00005579681,0.0001052757,0.0001186756,0.0001594915,4.89573e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002583823,"about_ca_system_score_gemma":0.0001424598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004560153,"about_ca_topic_score_gemma":0.0009737213,"domain_scores_codex":[0.9981358,0.0003806376,0.0005623768,0.0003919316,0.0002959113,0.0002333479],"domain_scores_gemma":[0.9989329,0.0002879401,0.0001446311,0.0003765614,0.0002332323,0.00002475445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001189456,0.0004748152,0.4146908,0.00004680345,0.0004026993,0.000001379862,0.0004795805,0.000007196993,0.5774019,0.00002777522,0.00001465195,0.005262983],"study_design_scores_gemma":[0.002969042,0.0003220727,0.5184813,0.0000509207,0.000527501,0.000002306136,0.0001831565,0.01326389,0.4640179,0.00008883666,0.00003435135,0.00005874539],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968028,0.002124951,0.000004803234,0.0002345617,0.00005468779,0.000612653,0.000008863053,0.00001751414,0.0001391297],"genre_scores_gemma":[0.9990926,0.0000624871,0.00005052751,0.0007330838,0.0000169605,0.00002767775,0.000009546915,0.00000595224,0.000001157566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.113384,"threshold_uncertainty_score":0.5382181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08589551286113246,"score_gpt":0.4032500063148407,"score_spread":0.3173544934537083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}