{"id":"W4412636643","doi":"10.3934/mbe.2025090","title":"Targeting stem cells with oncolytic viruses: a mathematical modelling approach","year":2025,"lang":"en","type":"article","venue":"Mathematical Biosciences & Engineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Oncolytic virus; Computational biology; Virology; Stem cell; Biology; Computer science; Virus; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007178569,0.0002683491,0.000295931,0.0001423799,0.0001338771,0.000128612,0.0005381961,0.0001287519,0.00002509401],"category_scores_gemma":[0.00004861625,0.0002025898,0.00008459352,0.0005123598,0.0001743544,0.00001372284,0.0001699873,0.0001924432,0.00003291427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004259559,"about_ca_system_score_gemma":0.0001297179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000121895,"about_ca_topic_score_gemma":5.134294e-7,"domain_scores_codex":[0.9980637,0.00003879488,0.0003558699,0.0005343108,0.0004215461,0.0005857769],"domain_scores_gemma":[0.9992291,0.0000867472,0.0000501098,0.0004191705,0.00006362316,0.0001512653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001385006,0.0002160767,0.00001576149,0.0003883153,0.00006817916,0.00000477064,0.0001614382,0.2449294,0.7477696,0.005885853,0.00008046057,0.0003416781],"study_design_scores_gemma":[0.0002868251,0.0004500051,6.083901e-7,0.0001327162,0.00002092313,0.000008180271,0.000252576,0.6502609,0.3474083,0.0004983941,0.0004050699,0.0002754814],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3552462,0.0002301845,0.6425679,0.00003997172,0.00004147711,0.0003342503,0.000003331028,0.00005738311,0.00147927],"genre_scores_gemma":[0.9350227,0.00002791073,0.06401166,0.0001268705,0.00007398536,0.0001037358,0.00000349944,0.00003987697,0.0005897519],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5797765,"threshold_uncertainty_score":0.8261373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119269978038919,"score_gpt":0.2663148198995474,"score_spread":0.2451221201191582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}