{"id":"W4412638115","doi":"10.1038/s41598-025-12770-5","title":"Exercise attenuates bed rest-induced increases in insulin resistance while α-klotho increases in 55 to 65 year-old women and men","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Spaceflight effects on biology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Research Institute for Aging; University of Waterloo","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Frailty Network; Canadian Space Agency; McGill University Health Centre","keywords":"Klotho; Rest (music); Insulin resistance; Bed rest; Medicine; Endocrinology; Insulin; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003006124,0.0002424557,0.0006529012,0.001074079,0.0001225839,0.0001049052,0.0001382772,0.0001689215,0.00008110871],"category_scores_gemma":[0.003024485,0.0002163758,0.00004405146,0.002162431,0.0002102437,0.0001275763,0.0002147941,0.0002498652,0.00003190717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220831,"about_ca_system_score_gemma":0.0003676027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002021872,"about_ca_topic_score_gemma":0.002171741,"domain_scores_codex":[0.9969812,0.0002128579,0.0007030458,0.001156403,0.0003592041,0.0005872597],"domain_scores_gemma":[0.9980631,0.0002866553,0.0001797207,0.001026029,0.0001514111,0.0002930276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001485712,0.0007351942,0.6871275,0.0003302177,0.00003927299,0.003267837,0.001417907,0.00000299391,0.2616335,0.0001071682,0.04102114,0.002831519],"study_design_scores_gemma":[0.002372142,0.0001855009,0.8997148,0.002385107,0.00004475098,0.00009506367,0.001333957,0.00002572107,0.07679269,0.003179644,0.01341816,0.0004524149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929785,0.001044866,6.979427e-7,0.0009144321,0.0004832955,0.001269257,0.000006636828,0.00008063486,0.003221701],"genre_scores_gemma":[0.9890218,0.00005534031,0.0003738673,0.0002501342,0.00003629208,0.000285153,0.00004170597,0.0000216078,0.009914118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2125873,"threshold_uncertainty_score":0.8823549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055066726547258,"score_gpt":0.2698379324951553,"score_spread":0.2592872652296827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}