{"id":"W4412641844","doi":"10.1021/acs.orglett.5c02925","title":"Strain Release Cycloadditions of 2H-Azirines: Access to Polycyclic Heterocycles","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Rouen; Centre National de la Recherche Scientifique; Normandie Université; Agence Nationale de la Recherche; Fonds de recherche du Québec – Nature et technologies; Région Normandie; Institut National des Sciences Appliquées Rouen; Canada Foundation for Innovation","keywords":"Cycloaddition; Chemistry; Azirine; Strain (injury); Steric effects; Selectivity; Combinatorial chemistry; Stereochemistry; Organic chemistry; Catalysis; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688972,0.0004085232,0.0002668425,0.0001987978,0.0002012498,0.0003653991,0.0003079943,0.0002363832,0.003613276],"category_scores_gemma":[0.0001428896,0.000185413,0.00025147,0.000170804,0.0002265907,0.0004657679,0.0003474342,0.000748398,0.0008609056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691125,"about_ca_system_score_gemma":0.0001677898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002360068,"about_ca_topic_score_gemma":0.0007023732,"domain_scores_codex":[0.9998884,0.00001185993,0.000006894519,0.00002773488,0.00002553519,0.00003960105],"domain_scores_gemma":[0.9999422,0.00001267198,0.00001593651,0.00001294159,0.000005987677,0.00001029667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002908671,0.0002011097,0.0003480281,0.0003293028,0.00003157177,0.0007584863,0.0002367161,0.003780747,0.9558104,0.01093279,0.0007492749,0.02653067],"study_design_scores_gemma":[0.00009407928,0.0009239086,0.001322697,0.0000225244,0.00002213804,0.0005566528,0.00005096295,0.003621921,0.9777402,0.000836849,0.01477109,0.00003702471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9260137,0.003426251,0.03239738,0.0002896597,0.0001499987,0.0002386125,0.0004850155,0.0002981601,0.03670131],"genre_scores_gemma":[0.9858109,0.002169097,0.006395285,0.00006465906,0.00003071643,0.00006379438,0.0002044329,0.00004771099,0.005213434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003613276,"threshold_uncertainty_score":0.01208758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200029744331281,"score_gpt":0.2585861039787966,"score_spread":0.2465858065354838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}