{"id":"W4412641844","doi":"10.1021/acs.orglett.5c02925","title":"Strain Release Cycloadditions of 2H-Azirines: Access to Polycyclic Heterocycles","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Rouen; Centre National de la Recherche Scientifique; Normandie Université; Agence Nationale de la Recherche; Fonds de recherche du Québec – Nature et technologies; Région Normandie; Institut National des Sciences Appliquées Rouen; Canada Foundation for Innovation","keywords":"Cycloaddition; Chemistry; Azirine; Strain (injury); Steric effects; Selectivity; Combinatorial chemistry; Stereochemistry; Organic chemistry; Catalysis; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004809905,0.0001437392,0.0001961308,0.0001246022,0.00009071542,0.00005962814,0.0004105027,0.00006877326,0.002250777],"category_scores_gemma":[0.000147925,0.0001434037,0.0001100085,0.0003078683,0.0000564152,0.0001315426,0.00009560194,0.0001283936,0.00008566694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108111,"about_ca_system_score_gemma":0.00005517351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008334019,"about_ca_topic_score_gemma":0.0000339187,"domain_scores_codex":[0.9990714,0.00001358837,0.000285263,0.0002669199,0.0001478945,0.0002149593],"domain_scores_gemma":[0.9991598,0.0001394811,0.00007939677,0.0005157578,0.00001711466,0.00008849603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000865664,0.00007301533,0.0007198608,0.00004251163,0.00007294314,0.000004530792,0.0000502837,0.000005276243,0.9717581,0.00007827241,0.02216696,0.005019653],"study_design_scores_gemma":[0.0002631157,0.000004033991,0.007713994,0.0001306117,0.00007573952,0.000007524405,0.000241782,0.000005572233,0.9786698,0.0001192161,0.01259061,0.000177981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768789,0.00002703349,0.0008099999,0.01498819,0.0001260245,0.00007328567,0.000151696,0.00008894126,0.006855893],"genre_scores_gemma":[0.9960388,0.00001385667,0.00009664991,0.003067075,0.00009744058,0.00003259858,0.00004969491,0.00002143127,0.0005824829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01915983,"threshold_uncertainty_score":0.9986613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200029744331281,"score_gpt":0.2585861039787966,"score_spread":0.2465858065354838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}