{"id":"W4412650692","doi":"10.1016/j.omtm.2025.101536","title":"Early postnatal expression mitigates immune responses to Cas9 in the murine central nervous system","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research","keywords":"Central nervous system; Immune system; Neuroscience; Expression (computer science); Biology; Immunology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039653,0.0002670173,0.0002048869,0.0002268467,0.00009167373,0.0003466625,0.0002326482,0.0003243233,0.001081767],"category_scores_gemma":[0.0001691567,0.0001560404,0.0001815164,0.0000671788,0.0002705439,0.0002668822,0.0001421956,0.0008671134,0.0003119275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000303807,"about_ca_system_score_gemma":0.0002546413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006947225,"about_ca_topic_score_gemma":0.001401094,"domain_scores_codex":[0.9998345,0.00002589981,0.00002205404,0.00003702857,0.0000403156,0.00004020613],"domain_scores_gemma":[0.9997823,0.00002732757,0.00008096636,0.00001992308,0.00002163558,0.00006791146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001625669,0.00003499629,0.000129168,0.00002844991,0.000003349724,0.00002768938,0.00001160483,0.00003251453,0.9983778,0.00008590758,0.0000380782,0.001067877],"study_design_scores_gemma":[0.00001661894,0.0005634391,0.002923763,0.00001202393,0.00001699777,0.0001675712,0.00001872585,0.0005028183,0.9940547,0.0000309601,0.001689085,0.000003306936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990864,0.001824605,0.004580094,0.0001683559,0.00007169546,0.00005933896,0.0004574966,0.0001886162,0.001785889],"genre_scores_gemma":[0.9907935,0.001129043,0.003457796,0.00007886127,0.00001588873,0.00005563128,0.0003555033,0.00006091609,0.004052678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081767,"threshold_uncertainty_score":0.003618836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03403242700887373,"score_gpt":0.3988296445102305,"score_spread":0.3647972175013567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}