{"id":"W4412654455","doi":"10.1002/alz.70509","title":"Distinct inflammatory profiles in young‐onset versus late‐onset Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arthritis Research Centre of Canada; Krembil Foundation; Research Canada; University Health Network; University of Toronto; Ontario Brain Institute; Occupational Cancer Research Centre; Discovery Centre","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Sanofi; Cure Alzheimer's Fund; Biogen; Fonds de Recherche du Québec - Santé; Foundation for the National Institutes of Health","keywords":"Adult-onset Still's disease; Early-onset Alzheimer's disease; Age of onset; Disease; Alzheimer's disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003364208,0.0004248469,0.0004988206,0.0007541411,0.0003056921,0.0004808501,0.0001104842,0.0002546782,0.0008098322],"category_scores_gemma":[0.0004714522,0.000146734,0.0001946125,0.0003936971,0.0002675053,0.0002968566,0.0003237089,0.0002087971,0.000201679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177323,"about_ca_system_score_gemma":0.0001250014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008010879,"about_ca_topic_score_gemma":0.001117349,"domain_scores_codex":[0.9998651,0.00002145769,0.00002293628,0.00003930773,0.00002581148,0.00002541403],"domain_scores_gemma":[0.9996188,0.00003995347,0.0002014419,0.00001371822,0.00005555825,0.00007061005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003271778,0.0001808318,0.9250496,0.0001678515,0.00009695053,0.001387345,0.0008499792,0.00004876081,0.05958941,0.00005016329,0.0001379243,0.009169347],"study_design_scores_gemma":[0.00001577541,0.0004453802,0.9956409,0.00001266083,0.00002968005,0.001723505,0.0002585223,0.00004441732,0.001580645,0.00003906261,0.0002047838,0.000004781701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988413,0.0008092474,0.00007832319,0.000007278337,0.00000462334,0.000006972938,0.0000746778,0.000003194295,0.0001743506],"genre_scores_gemma":[0.9990156,0.0003656817,0.000200681,0.00002308115,0.00001365825,0.00001109496,0.0001657778,0.000001806602,0.0002025194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008098322,"threshold_uncertainty_score":0.002709091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641522563201403,"score_gpt":0.3148034979102856,"score_spread":0.2883882722782715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}