{"id":"W4412657782","doi":"10.1016/j.vaccine.2025.127504","title":"Longitudinal Meta-cohort study protocol using systems biology to identify vaccine safety biomarkers","year":2025,"lang":"en","type":"article","venue":"Vaccine","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Women and Children’s Health Research Institute; University of Ottawa; BC Children's Hospital; University of Toronto; McMaster University; University of Alberta","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration; Istituto di Ricovero e Cura a Carattere Scientifico; Centers for Disease Control and Prevention; Ministero della Salute; Department of Health and Ageing, Australian Government; Coalition for Epidemic Preparedness Innovations","keywords":"Medicine; Vaccination; Pharmacogenomics; Bioinformatics; Intensive care medicine; Immunology; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03081528,0.00202982,0.003350772,0.002312224,0.001106635,0.002305974,0.002344096,0.002351816,0.02751077],"category_scores_gemma":[0.04864728,0.001544312,0.005436482,0.002992883,0.0006899524,0.001190018,0.001834788,0.003800694,0.003973013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001624329,"about_ca_system_score_gemma":0.006443415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004949634,"about_ca_topic_score_gemma":0.008041631,"domain_scores_codex":[0.9869856,0.007692418,0.002214388,0.00191139,0.0007967467,0.0003992997],"domain_scores_gemma":[0.9828531,0.0064013,0.001465269,0.006680093,0.002151259,0.0004489441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.104929,0.001170525,0.06020412,0.09029789,0.07972449,0.00231167,0.001860692,0.02118577,0.007380378,0.06621758,0.4319544,0.1327635],"study_design_scores_gemma":[0.1045759,0.006771426,0.08747837,0.01522479,0.06027468,0.001486323,0.0005291726,0.02742731,0.003706469,0.08172812,0.6100724,0.0007250487],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02047952,0.006867077,0.1656639,0.004425574,0.002416288,0.4126179,0.3749611,0.002076286,0.01049239],"genre_scores_gemma":[0.03096655,0.001485212,0.04913031,0.001624762,0.0002432419,0.8554147,0.05628141,0.0001689886,0.004684872],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03081528,"threshold_uncertainty_score":0.1629687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648968962670866,"score_gpt":0.3484257983127954,"score_spread":0.3119361086860867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}