{"id":"W4412661821","doi":"10.1093/humrep/deaf144","title":"Methodological concerns and clinical relevance: a critical appraisal of the meta-analysis on biosimilars versus originator follitropin alfa in ART","year":2025,"lang":"en","type":"letter","venue":"Human Reproduction","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Conversant (Canada)","funders":"","keywords":"Critical appraisal; Biosimilar; Meta-analysis; Relevance (law); Medicine; MEDLINE; Intensive care medicine; Internal medicine; Alternative medicine; Political science; Pathology; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.003472553,0.0004330616,0.002374324,0.0003459359,0.0001664101,0.00002373739,0.0004186296,0.001977836,0.0007235376],"category_scores_gemma":[0.01185206,0.0002655119,0.001885559,0.0007440484,0.001839588,0.00003526018,0.0002164859,0.003290968,0.00001119925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006456867,"about_ca_system_score_gemma":0.00007135487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003728606,"about_ca_topic_score_gemma":0.00004000876,"domain_scores_codex":[0.9909921,0.005529095,0.001200952,0.001687608,0.0001616444,0.0004285597],"domain_scores_gemma":[0.9896996,0.008244421,0.0004107347,0.001449274,0.0001710108,0.00002498513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008460714,0.0003668787,0.0006453272,0.0001954972,0.05254413,0.00003016457,0.00003101,0.000003774623,0.0009857396,0.005365196,0.9373612,0.001624987],"study_design_scores_gemma":[0.0008727829,0.0006148741,0.001626082,0.00003140593,0.08697398,0.000007997372,0.00002218238,0.000003016719,0.003077352,0.001424213,0.9050037,0.0003424421],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003121888,0.008840498,0.0005555676,0.9726394,0.01126722,0.001004296,0.000310315,0.00009731829,0.002163466],"genre_scores_gemma":[0.1057994,0.005792961,0.03315134,0.7052301,0.01760971,0.0009272489,0.001813961,0.0003808388,0.1292944],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2674093,"threshold_uncertainty_score":0.9999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3683354351754387,"score_gpt":0.4976417602416229,"score_spread":0.1293063250661842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}