{"id":"W4412662543","doi":"10.14740/wjon2583","title":"Clinical Utility of Targeted Next-Generation Sequencing for Determining Human Epidermal Growth Factor Receptor 2 Status and Optimizing Targeted Therapy in Breast Cancer","year":2025,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Human Epidermal Growth Factor Receptor 2; Targeted therapy; Breast cancer; Epidermal growth factor receptor; Oncology; Cancer; DNA sequencing; Cancer research; Internal medicine; Gene; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00181712,0.0002528479,0.0002746374,0.0006275979,0.0001320861,0.0004766383,0.0001942535,0.0003736866,0.0007337578],"category_scores_gemma":[0.002431926,0.00009073626,0.0001358017,0.0002818795,0.0002927908,0.0002951912,0.0001962193,0.0002657659,0.0001520642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004277699,"about_ca_system_score_gemma":0.0003018323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000582767,"about_ca_topic_score_gemma":0.0009569894,"domain_scores_codex":[0.999559,0.0001722426,0.00002522325,0.0000770823,0.0001339369,0.00003247191],"domain_scores_gemma":[0.9992985,0.0003667149,0.0001166499,0.00004148679,0.0001296484,0.00004714183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004055357,0.0003139562,0.4699526,0.000314436,0.0001869583,0.0006858004,0.0001925558,0.005998386,0.2062427,0.0004519978,0.001521374,0.3100839],"study_design_scores_gemma":[0.0001835028,0.004353262,0.7430493,0.0001808619,0.0004745059,0.008833185,0.0003724111,0.05224998,0.1790254,0.00244616,0.008777849,0.00005357221],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773206,0.00995587,0.008443412,0.0004299881,0.00003888468,0.00008397562,0.0002302775,0.0001217125,0.003375238],"genre_scores_gemma":[0.9916499,0.001366189,0.006356461,0.0001490722,0.00002289155,0.00002576979,0.0001610365,0.0000070448,0.0002615907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181712,"threshold_uncertainty_score":0.009609997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2003398553900288,"score_gpt":0.4655593231436879,"score_spread":0.265219467753659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}