{"id":"W4412676182","doi":"10.1080/23995270.2025.2535273","title":"A plain language summary of the phase 1/2 study of AAV5-hRKp.RPGR (botaretigene sparoparvovec) in people with RPGR-associated X-linked retinitis pigmentosa","year":2025,"lang":"en","type":"article","venue":"Future Rare Diseases","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kellogg's (Canada)","funders":"Johnson and Johnson; Moorfields Eye Hospital NHS Foundation Trust; National Institute for Health and Care Research","keywords":"Retinitis pigmentosa; Phase (matter); Medicine; Physics; Ophthalmology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006921269,0.001265468,0.002077951,0.0009250887,0.0007601593,0.002444173,0.001136434,0.0027431,0.1269561],"category_scores_gemma":[0.01875784,0.0006423471,0.002509156,0.0007696273,0.0003726848,0.001311768,0.0006310456,0.002648985,0.02200722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001369243,"about_ca_system_score_gemma":0.002860991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003043487,"about_ca_topic_score_gemma":0.004464489,"domain_scores_codex":[0.9963606,0.001914462,0.0007569966,0.0002259262,0.0005820152,0.0001601136],"domain_scores_gemma":[0.9871727,0.006271883,0.001993353,0.0003333026,0.003353113,0.0008755808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01651347,0.0008074342,0.0008327027,0.02152603,0.0005903322,0.0002720485,0.0001250102,0.0002291628,0.00196282,0.001058278,0.845452,0.1106308],"study_design_scores_gemma":[0.02224693,0.01506165,0.006234549,0.0204055,0.001385188,0.0005099564,0.0001997967,0.0002091694,0.001238608,0.001676643,0.9307178,0.0001141795],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"other","genre_scores_codex":[0.01885761,0.2004831,0.01272074,0.202371,0.06818182,0.07046741,0.2475458,0.002190246,0.1771823],"genre_scores_gemma":[0.06489857,0.1853235,0.02558837,0.2816062,0.03674272,0.08600239,0.06793655,0.001374529,0.2505272],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1269561,"threshold_uncertainty_score":0.4247105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003337129755909234,"score_gpt":0.2396379515389264,"score_spread":0.2363008217830172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}