{"id":"W4412679455","doi":"10.1101/2025.07.25.25332228","title":"International Multi-site Implementation of Local Cell-Free Protein Biomanufacturing to Advance Health and Research Equity","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Emmanuel Bible College; IMPCO Technologies (Canada); University of Toronto","funders":"CHIST-ERA; Canadian Institutes of Health Research; Shastri Indo-Canadian Institute; Agencia Nacional de Investigación y Desarrollo; Indian Institute of Science Education and Research Mohali; Ministry of Colleges and Universities; Indian Institute of Science Education and Research Pune; Agenția Națională pentru Cercetare și Dezvoltare; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Institutes of Health; Canada Research Chairs; International Development Research Centre; CYTED Ciencia y Tecnología para el Desarrollo; University of Toronto","keywords":"Biomanufacturing; Equity (law); Business; Political science; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["open_science"],"consensus_categories":[],"category_scores_codex":[0.01448443,0.000801209,0.0004243637,0.0009830091,0.001097054,0.002622952,0.001947537,0.00150237,0.0114967],"category_scores_gemma":[0.004183328,0.0002799834,0.0008802611,0.0007980628,0.002145307,0.002354075,0.007805354,0.002799739,0.00232167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002337123,"about_ca_system_score_gemma":0.009901302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00237722,"about_ca_topic_score_gemma":0.00309285,"domain_scores_codex":[0.9958134,0.001569636,0.0001628793,0.000839875,0.000969348,0.0006448327],"domain_scores_gemma":[0.9936681,0.0008820028,0.0008318662,0.001438879,0.00159488,0.001584176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001296496,0.002362139,0.009741496,0.002372735,0.0003353246,0.0008246794,0.002508044,0.016738,0.172701,0.1338212,0.06219741,0.5951015],"study_design_scores_gemma":[0.0007621851,0.005095338,0.01447469,0.0006699347,0.000202525,0.001081375,0.002210237,0.01658878,0.1526802,0.04613688,0.7598813,0.000216552],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.172008,0.01466563,0.6155462,0.037035,0.004369993,0.004056652,0.002335705,0.005785599,0.1441971],"genre_scores_gemma":[0.678804,0.006712828,0.2690856,0.005375338,0.0005123253,0.002183576,0.002393124,0.0006226017,0.03431066],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9980525,"threshold_uncertainty_score":0.07660192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042084911312861,"score_gpt":0.4891772292764831,"score_spread":0.384968738145197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}