{"id":"W4412687361","doi":"10.1177/13872877251359680","title":"Obesity-related brain atrophy is independent of Alzheimer's disease protein pathways","year":2025,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Neurodegeneration; Atrophy; Apolipoprotein E; Disease; Tau protein; Obesity; Internal medicine; Medicine; Psychology; Alzheimer's disease; Neuroscience; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005719764,0.0005126827,0.0003781543,0.0008138756,0.0002343987,0.0006937105,0.0002579658,0.0002269295,0.001913515],"category_scores_gemma":[0.001454406,0.0002654927,0.0004229671,0.0005385695,0.0004434513,0.0004280054,0.0005799336,0.0003701718,0.0003008317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988061,"about_ca_system_score_gemma":0.0003140602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002644328,"about_ca_topic_score_gemma":0.003251578,"domain_scores_codex":[0.9997169,0.00006893866,0.00003107836,0.0000840863,0.00005815058,0.00004072442],"domain_scores_gemma":[0.9990049,0.0001885087,0.0005310344,0.00009988884,0.0001061937,0.00006950487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004891662,0.0003003657,0.8733485,0.0009728611,0.002387194,0.001698254,0.0003892077,0.0005374125,0.05296297,0.002266852,0.001092152,0.05915262],"study_design_scores_gemma":[0.00001700373,0.0001244098,0.9961665,0.0000421714,0.0001457532,0.0007364362,0.00003759125,0.000185061,0.0007837895,0.001055294,0.0007010744,0.000004766305],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846465,0.00738069,0.001383316,0.0003138135,0.0000305227,0.00005160051,0.0008416189,0.00003773806,0.00531416],"genre_scores_gemma":[0.9941954,0.003095435,0.0007356778,0.0001151434,0.0000348637,0.00003673835,0.0006760624,0.000009095843,0.001101634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002644328,"threshold_uncertainty_score":0.00640136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02335631195686418,"score_gpt":0.3011085449472081,"score_spread":0.2777522329903439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}