{"id":"W4412692141","doi":"10.1038/s41551-025-01461-1","title":"Efficient and sustained optogenetic control of sensory and cardiac systems","year":2025,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Optogenetics; Channelrhodopsin; Neuroscience; Stimulation; Halorhodopsin; Sensory system; Depolarization; Biology; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220711,0.0001094169,0.0002181191,0.0002320546,0.00003794443,0.00002481677,0.0001108225,0.0002177158,0.000002684668],"category_scores_gemma":[0.0007970992,0.00009300555,0.00003147591,0.0003348676,0.0001620548,0.000007904296,0.00008174629,0.0003266874,4.404984e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002915592,"about_ca_system_score_gemma":0.0000449606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004265021,"about_ca_topic_score_gemma":2.822502e-8,"domain_scores_codex":[0.9989581,0.00004499114,0.0001646864,0.0002522843,0.0003321936,0.0002477846],"domain_scores_gemma":[0.9992601,0.0003952056,0.00001960594,0.0001305496,0.00004077612,0.0001537177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00002344201,0.00002014108,0.0002271181,0.0003079607,0.00001537196,0.000007215314,0.00003274459,0.001218651,0.9945643,0.00276397,0.00004228645,0.000776834],"study_design_scores_gemma":[0.001677676,0.0001326169,0.003946106,0.0002060154,0.00004161818,0.00001131878,0.00009224061,0.6230564,0.3561317,0.00001525578,0.014417,0.0002720689],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832609,0.0109063,0.00419054,0.0001486529,0.0008177077,0.0003674287,0.00005976183,0.00004664617,0.0002020963],"genre_scores_gemma":[0.9995615,0.0001514108,0.00008291374,0.00003047991,0.00005368523,0.00001188634,9.458014e-7,0.000009083178,0.00009812302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6384326,"threshold_uncertainty_score":0.3792656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005041290929480823,"score_gpt":0.2576068180750539,"score_spread":0.2525655271455731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}