{"id":"W4412694942","doi":"10.3390/vaccines13080794","title":"Epitope Profiling of SARS-CoV-2 Spike Antigen Provides a Novel Strategy for Developing ELISAs Specific for Different Spike Protein Variants in Bivalent Vaccine Formulations","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Biomedical Advanced Research and Development Authority; Sanofi; U.S. Department of Health and Human Services; U.S. Department of Defense","keywords":"Bivalent (engine); Epitope; Antigen; Reverse vaccinology; Monoclonal antibody; Spike Protein; Virology; Biology; Antibody; Computational biology; Chemistry; Coronavirus disease 2019 (COVID-19); Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004638424,0.0006304742,0.0002214979,0.0005011291,0.0001186341,0.0003433044,0.0003132354,0.0003712364,0.0006668065],"category_scores_gemma":[0.0004084554,0.0001889745,0.0002228687,0.000191222,0.0001792495,0.0002845551,0.0003560876,0.0006203523,0.0003013464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002913134,"about_ca_system_score_gemma":0.00016807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003000474,"about_ca_topic_score_gemma":0.0006834001,"domain_scores_codex":[0.9997068,0.0000494203,0.00001728336,0.00007649608,0.0001124144,0.00003755219],"domain_scores_gemma":[0.9997782,0.00005330924,0.00005124871,0.00002491874,0.00006894821,0.00002326269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000201152,0.00001785335,0.0004512131,0.00001705519,0.00000428216,0.000006230203,0.000007850796,0.00008301561,0.9968575,0.00005432259,0.00002142978,0.002459173],"study_design_scores_gemma":[0.000004951857,0.0001525199,0.002428799,0.000003357317,0.000009440465,0.0001105333,0.00001344985,0.002384426,0.9939965,0.00005627381,0.0008350962,0.00000457029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8881857,0.00102531,0.1071207,0.000148388,0.0000407178,0.0001615413,0.0005324795,0.0002744679,0.002510496],"genre_scores_gemma":[0.9088281,0.0006057727,0.08806735,0.0002744143,0.00002038359,0.0001012926,0.0006802559,0.00002803185,0.001394326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006668065,"threshold_uncertainty_score":0.002453089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1189908844355842,"score_gpt":0.3922295680843038,"score_spread":0.2732386836487196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}