{"id":"W4412695385","doi":"10.3390/ijms26157273","title":"Sciatic Integrity Is Necessary for Fast and Efficient Scrapie Infection After Footpad Injection","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Ministero della Salute","keywords":"Scrapie; Sciatic nerve; Infectivity; Incubation period; Peripheral; Slow virus; Central nervous system; In vivo; Virology; Peripheral nervous system; Biology; Medicine; Neuroscience; Prion protein; Pathology; Incubation; Anatomy; Internal medicine; Virus; Viral disease; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065946,0.0002237003,0.0003520778,0.0002614866,0.0001782852,0.0005745342,0.0001684771,0.0003825734,0.004410222],"category_scores_gemma":[0.0003832079,0.0001852577,0.0002837491,0.0001146604,0.0002905091,0.0003493688,0.0002998215,0.0008249164,0.00137951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764012,"about_ca_system_score_gemma":0.0003757121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269557,"about_ca_topic_score_gemma":0.001875335,"domain_scores_codex":[0.9998034,0.000026309,0.00001706994,0.00003185203,0.00006026449,0.00006109635],"domain_scores_gemma":[0.9995685,0.00006476189,0.0001205507,0.00005542628,0.00007986555,0.0001108543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002402196,0.00005545782,0.0005093791,0.00009320267,0.000007408931,0.0001211264,0.00004711207,0.00004854869,0.9957926,0.0001951428,0.0001113516,0.002778449],"study_design_scores_gemma":[0.00004909558,0.003310095,0.1064162,0.0001803947,0.00006211533,0.001429252,0.0003527114,0.001876243,0.8756076,0.0002743688,0.01041709,0.0000248483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777421,0.003600232,0.007495957,0.0001917659,0.0001587457,0.0001300495,0.0007611986,0.000327154,0.009592729],"genre_scores_gemma":[0.9867098,0.001238775,0.003389203,0.0000784141,0.00002299924,0.00005795501,0.0007440979,0.00004705521,0.007711643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004410222,"threshold_uncertainty_score":0.0147537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008570175244993478,"score_gpt":0.3020596445954556,"score_spread":0.2934894693504622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}