{"id":"W4412695519","doi":"10.1097/jcp.0000000000002046","title":"A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Psychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Anhedonia; Placebo; Major depressive disorder; Internal medicine; Rating scale; Clinical Global Impression; Depression (economics); Randomized controlled trial; Clinical endpoint; Psychology; Hamilton Rating Scale for Depression; Medicine; Psychiatry; Schizophrenia (object-oriented programming); Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116825,0.001369743,0.002344933,0.000377245,0.0003825145,0.0007700447,0.0007922265,0.00137241,0.008808657],"category_scores_gemma":[0.001043359,0.0006870109,0.000952479,0.0002649798,0.0006376776,0.000684794,0.0003364346,0.002014178,0.001401085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005400404,"about_ca_system_score_gemma":0.001139666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007571894,"about_ca_topic_score_gemma":0.002526263,"domain_scores_codex":[0.9996592,0.0001648704,0.00002143209,0.00006447061,0.00002945218,0.000060587],"domain_scores_gemma":[0.9995375,0.0000949391,0.0001214771,0.00003572549,0.0000400557,0.0001704183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9622042,0.01202135,0.0008979045,0.000622878,0.0006961779,0.00007885558,0.00006042644,0.000299783,0.00504254,0.0001264719,0.001179432,0.0167701],"study_design_scores_gemma":[0.9401956,0.05699904,0.001698803,0.00002129242,0.0001481389,0.00003730673,0.0000186012,0.0002136858,0.0001633334,0.00006476515,0.0004314056,0.000008088909],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831887,0.00326832,0.0005740097,0.0007303765,0.0005329822,0.007521593,0.001503028,0.000134254,0.002546909],"genre_scores_gemma":[0.9756118,0.002730325,0.002123157,0.001755445,0.0004396829,0.01076142,0.001825801,0.00002342781,0.004728964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008808657,"threshold_uncertainty_score":0.02946782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449033070190319,"score_gpt":0.4271596692931415,"score_spread":0.3926693385912383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}