{"id":"W4412695610","doi":"10.1002/marc.202500419","title":"Self‐Immolative Polyion Complexes","year":2025,"lang":"en","type":"article","venue":"Macromolecular Rapid Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Depolymerization; Chemistry; Micelle; Cationic polymerization; Polyelectrolyte; Biophysics; Polymer; Aqueous solution; Cytotoxicity; Combinatorial chemistry; Polymer chemistry; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302269,0.0001516903,0.0001325987,0.00009133769,0.0002808917,0.00004810662,0.0009852708,0.0001064878,0.00003103148],"category_scores_gemma":[0.00004241093,0.0001621903,0.0001286273,0.0002237096,0.0001409708,0.000004807679,0.0006486592,0.0001355198,0.0000493424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002034509,"about_ca_system_score_gemma":0.00009118958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000034056,"about_ca_topic_score_gemma":0.00003861357,"domain_scores_codex":[0.9990477,0.0001864044,0.0002208217,0.0002679689,0.00007996017,0.0001971218],"domain_scores_gemma":[0.9979352,0.00002210929,0.00006373058,0.001799189,0.0001431365,0.00003667237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004257012,0.0002889717,0.0005765117,0.00002044444,0.0003556898,0.000002513385,0.0001754608,0.00001106927,0.9699211,0.01017284,0.006786061,0.01164683],"study_design_scores_gemma":[0.0006044384,0.0001984209,0.001990115,0.00004621267,0.00007289732,0.00001449372,0.0002197964,0.0007270531,0.4147954,0.001201024,0.5797981,0.0003320556],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.656407,0.04719557,0.06650885,0.008503556,0.0005161285,0.001315238,0.0001277233,0.0002850395,0.2191409],"genre_scores_gemma":[0.9903758,0.001577826,0.00526069,0.001242554,0.00001973138,0.00006976417,0.0003404497,0.00001514188,0.001098108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5730121,"threshold_uncertainty_score":0.6613929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311230902586095,"score_gpt":0.2861891445856276,"score_spread":0.2730768355597666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}