{"id":"W4412695610","doi":"10.1002/marc.202500419","title":"Self‐Immolative Polyion Complexes","year":2025,"lang":"en","type":"article","venue":"Macromolecular Rapid Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Depolymerization; Chemistry; Micelle; Cationic polymerization; Polyelectrolyte; Biophysics; Polymer; Aqueous solution; Cytotoxicity; Combinatorial chemistry; Polymer chemistry; In vitro; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608997,0.000458494,0.0001776645,0.0001946477,0.0001187653,0.0003558746,0.0002270479,0.0002973186,0.002332022],"category_scores_gemma":[0.0002536986,0.0001082061,0.0001266817,0.00012158,0.0001478125,0.0002527433,0.0002954843,0.0004125408,0.0007973927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003332832,"about_ca_system_score_gemma":0.0001340883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000156521,"about_ca_topic_score_gemma":0.0001460301,"domain_scores_codex":[0.9997774,0.00003011739,0.00002139908,0.00005829903,0.00006993068,0.00004283604],"domain_scores_gemma":[0.9998848,0.00002324692,0.00002560756,0.00001308809,0.00002228488,0.00003083231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006101194,0.00002118186,0.00004620266,0.00004669168,0.000008424294,0.00004922799,0.0000178622,0.0001678133,0.9963182,0.000432576,0.0001814438,0.002649294],"study_design_scores_gemma":[0.00002595117,0.0001525337,0.0001749214,0.000004393734,0.000007809534,0.00007639492,0.000003394363,0.0007094838,0.9912683,0.00004782468,0.007525092,0.000003848944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534993,0.00434989,0.02432446,0.000271863,0.0002551413,0.000265625,0.0003589109,0.0006272321,0.01604758],"genre_scores_gemma":[0.9784948,0.0009995952,0.007198132,0.0001679545,0.00003778828,0.0001245649,0.0005424685,0.00005637179,0.01237832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002332022,"threshold_uncertainty_score":0.007801414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311230902586095,"score_gpt":0.2861891445856276,"score_spread":0.2730768355597666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}