{"id":"W4412697281","doi":"10.1007/978-1-0716-4730-1_4","title":"Milasen: The Emerging Era of Patient-Customized N-of-1 Antisense Oligonucleotides as Therapeutic Agents for Genetic Diseases","year":2025,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Oligonucleotide; Computational biology; Computer science; Biology; Medicine; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087272,0.0007064854,0.0003819194,0.0004544799,0.0001941609,0.001146509,0.0004756389,0.0007648261,0.003191714],"category_scores_gemma":[0.0005478176,0.0002116746,0.000221112,0.0002386643,0.0004947595,0.00103657,0.0008931363,0.001594046,0.001248988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005795637,"about_ca_system_score_gemma":0.0005388403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142045,"about_ca_topic_score_gemma":0.0004973078,"domain_scores_codex":[0.9996946,0.00009293434,0.00001849247,0.00006861998,0.00008202655,0.0000434475],"domain_scores_gemma":[0.9997771,0.00006277937,0.00005635863,0.00001920751,0.00003261595,0.00005181914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005920962,0.0001444427,0.0005843354,0.0006702659,0.00003770086,0.0003186562,0.0001960901,0.0007715405,0.7944549,0.03854728,0.005398179,0.1582845],"study_design_scores_gemma":[0.0001172253,0.001091559,0.001032327,0.0001764643,0.0000654988,0.001701057,0.0001086681,0.002617309,0.6738644,0.006817006,0.3123535,0.00005505356],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.3670119,0.2502738,0.2483478,0.0290843,0.00416111,0.0007347311,0.002244682,0.004215423,0.09392624],"genre_scores_gemma":[0.7130368,0.1177268,0.09402885,0.01088122,0.001200913,0.0006703456,0.002239406,0.0005199133,0.05969577],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003191714,"threshold_uncertainty_score":0.01067734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374140726005757,"score_gpt":0.3757836670419155,"score_spread":0.3620422597818579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}