{"id":"W4412697347","doi":"10.1128/jvi.00898-25","title":"The vaccinia virus protein, C16, promotes the ubiquitylation and relocalization of the antiviral E3 ubiquitin-ligase, TRIM25","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Centre for Advancing Health Outcomes","funders":"Li Ka Shing Institute of Virology, University of Alberta; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Biology; Ubiquitin ligase; Vaccinia; Ubiquitin; Innate immune system; Cell biology; Proteasome; Virology; Virus; ISG15; Viral replication; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001447558,0.0003881888,0.0001682843,0.0002517985,0.0001974947,0.0003199668,0.0001464161,0.0002646433,0.0009884429],"category_scores_gemma":[0.0001476328,0.0002116055,0.0003042258,0.0001118669,0.0002389899,0.0002154505,0.0002472739,0.0003419814,0.0003943592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004753714,"about_ca_system_score_gemma":0.0002361964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007934617,"about_ca_topic_score_gemma":0.0009777653,"domain_scores_codex":[0.9998746,0.00001738164,0.00001207793,0.00002833482,0.00002069455,0.00004694127],"domain_scores_gemma":[0.9998517,0.00002243315,0.00004277179,0.00002446814,0.00001387145,0.00004472688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005716,0.00001445367,0.0002903232,0.0000221943,0.000004213958,0.00003916166,0.000009068471,0.00002469913,0.9991207,0.0000455686,0.00001796326,0.0003111422],"study_design_scores_gemma":[0.00001771975,0.0002392724,0.01649047,0.000009480208,0.00001266833,0.0004038122,0.00003589588,0.001022146,0.9798094,0.00005476078,0.001899467,0.000004972537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980579,0.0009286102,0.0003977725,0.00002177335,0.00001280275,0.000009109905,0.00009153697,0.00001825286,0.0004620527],"genre_scores_gemma":[0.9977622,0.0003394792,0.0004693321,0.00001524344,0.000004615352,0.00001008649,0.0002404364,0.00001137861,0.001147163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009884429,"threshold_uncertainty_score":0.003449142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007636161814424025,"score_gpt":0.2623710128451526,"score_spread":0.2547348510307286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}