{"id":"W4412700371","doi":"10.1001/jamaneurol.2025.2565","title":"Modulation of Treatment Effect on Disability by Disease Activity in Progressive Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada); Montreal Neurological Institute and Hospital","funders":"","keywords":"Multiple sclerosis; Disease; Medicine; Clinical trial; Lesion; Physical medicine and rehabilitation; Oncology; Internal medicine; Physical therapy; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02399913,0.002239613,0.009250224,0.002022511,0.0005557206,0.002705606,0.001381406,0.002094519,0.002211649],"category_scores_gemma":[0.0336171,0.0008840052,0.03206399,0.002215045,0.0007786456,0.001103931,0.001222871,0.002627094,0.0002253826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008008025,"about_ca_system_score_gemma":0.0006223408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002150641,"about_ca_topic_score_gemma":0.003980356,"domain_scores_codex":[0.9770523,0.01683429,0.002545788,0.001998594,0.001196314,0.0003727119],"domain_scores_gemma":[0.9699302,0.02352991,0.003039345,0.002291786,0.0008980302,0.0003107848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.01623733,0.00003949328,0.01124354,0.01192467,0.9527078,0.00005814628,0.0000519273,0.0004685743,0.0006147363,0.0001128146,0.0002917059,0.006249272],"study_design_scores_gemma":[0.003449577,0.00118065,0.01700629,0.0008153099,0.9754393,0.00008540496,0.00002840813,0.0002431898,0.0003363856,0.0002997578,0.001096967,0.00001872266],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1560176,0.8338305,0.004056315,0.0009653106,0.001052096,0.0003508654,0.001558902,0.0001282595,0.002040104],"genre_scores_gemma":[0.94708,0.04759526,0.002066492,0.0009929069,0.0005000462,0.0002672275,0.0008768337,0.00006121377,0.0005601101],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02399913,"threshold_uncertainty_score":0.1269211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03834780336508917,"score_gpt":0.331018066665521,"score_spread":0.2926702633004319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}