{"id":"W4412700966","doi":"10.1186/s13023-025-03739-8","title":"Unmet needs in hereditary angioedema: an international survey of physicians","year":2025,"lang":"en","type":"article","venue":"Orphanet Journal of Rare Diseases","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"CSL Limited; Grifols; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Glenmark Pharmaceuticals; Argenx; Celltrion; Pfizer; Incyte; LEO Pharma; Charité – Universitätsmedizin Berlin; Kiniksa Pharmaceuticals; BioCryst; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Galderma; Ono Pharmaceutical; Eli Lilly and Company; AstraZeneca; CSL Behring; Amgen; Pennsylvania State University; Menarini Group; Swedish Orphan Biovitrum; University of Pennsylvania; Regeneron Pharmaceuticals; Ionis Pharmaceuticals; Canadian Blood Services; Teva Pharmaceutical Industries; Workplace Safety and Insurance Board; Sanofi; Celldex Therapeutics","keywords":"Hereditary angioedema; Medicine; Family medicine; Reimbursement; Angioedema; Health care; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002032497,0.0001486674,0.0002341177,0.001221486,0.000372807,0.0006437601,0.0002644516,0.0005710791,0.001600781],"category_scores_gemma":[0.008268383,0.0001900267,0.0003457806,0.001512822,0.0003197174,0.0009866073,0.000930872,0.0005695747,0.0002556762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005510006,"about_ca_system_score_gemma":0.0005669355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005604607,"about_ca_topic_score_gemma":0.0047447,"domain_scores_codex":[0.9981626,0.0005733656,0.0003494984,0.0001979276,0.000464881,0.0002517772],"domain_scores_gemma":[0.9915845,0.001781944,0.004288427,0.000195484,0.0008095854,0.00134005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003001535,0.00004337009,0.9934893,0.0000565931,0.00002930973,0.00009092795,0.001773721,0.0000457879,0.0000933358,0.00003658734,0.0008897277,0.003421388],"study_design_scores_gemma":[0.000005829264,0.00009820941,0.9945487,0.00005208038,0.00001021987,0.0003112905,0.003742218,0.000144085,0.00003441131,0.00002377604,0.001022403,0.000006589189],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963438,0.0003878164,0.00005737229,0.0007890898,0.0000117134,0.00002746189,0.0009556105,0.000005067649,0.001422004],"genre_scores_gemma":[0.9985875,0.00032762,0.0001251301,0.0003140129,0.00001260636,0.00002992524,0.0004545381,0.000002357653,0.0001464422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005604607,"threshold_uncertainty_score":0.01114392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731783601450037,"score_gpt":0.2968972244093608,"score_spread":0.2795793883948605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}