{"id":"W4412702961","doi":"10.1371/journal.pbio.3003283","title":"Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice","year":2025,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institutes of Health; Wellcome Trust","keywords":"Thymic involution; Biology; Involution (esoterism); CD8; Immune system; T cell; Immunology; Immunity; Cell biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290482,0.0004690514,0.0004121016,0.0005625882,0.0001504134,0.0003462619,0.0002564202,0.0003276274,0.0009458065],"category_scores_gemma":[0.0001755095,0.0001715189,0.0002358408,0.0001316723,0.0002979894,0.0003371229,0.0003375869,0.0006431932,0.0002976336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776521,"about_ca_system_score_gemma":0.0001487841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691733,"about_ca_topic_score_gemma":0.0003461406,"domain_scores_codex":[0.9998028,0.00003438064,0.00002538614,0.00004652379,0.00003728632,0.00005361713],"domain_scores_gemma":[0.9996818,0.00002215666,0.0001037356,0.00003457451,0.00002193763,0.0001359078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000355598,0.0001148656,0.0002784986,0.00003988622,0.000006956038,0.00005312893,0.00002741682,0.0000942363,0.9957878,0.0001387915,0.00003870084,0.003064002],"study_design_scores_gemma":[0.0001268633,0.004114674,0.01143495,0.00004029029,0.00007933466,0.0007093364,0.00007287833,0.001468812,0.9762986,0.0002760196,0.005361899,0.00001620029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928874,0.002221308,0.0032204,0.00008605418,0.00005169273,0.0000337282,0.000274483,0.0001614724,0.001063505],"genre_scores_gemma":[0.9926329,0.001370785,0.002657089,0.0001001488,0.00004381299,0.00004599433,0.0003210657,0.00004922434,0.002778992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009458065,"threshold_uncertainty_score":0.003164053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244387256608786,"score_gpt":0.3033788503864946,"score_spread":0.2809349778204067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}