{"id":"W4412703186","doi":"10.1101/cshperspect.a041891","title":"The Mitochondrial Connection in Parkinson's Disease","year":2025,"lang":"en","type":"article","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Connection (principal bundle); Parkinson's disease; Neuroscience; Medicine; Disease; Biology; Internal medicine; Mathematics; Geometry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002653696,0.0001193738,0.0001470599,0.0001339217,0.0000979196,0.00001173434,0.0001602882,0.00008986826,0.00002261015],"category_scores_gemma":[0.001263836,0.0000936072,0.00004185751,0.0002500444,0.0002151566,0.000003222512,0.00005789968,0.0001857493,0.00000352133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007211111,"about_ca_system_score_gemma":0.00009012198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007719627,"about_ca_topic_score_gemma":0.0002963353,"domain_scores_codex":[0.9989789,0.000138107,0.0002052539,0.0003793519,0.00009122664,0.0002071802],"domain_scores_gemma":[0.9994482,0.00006756634,0.00004307723,0.000329829,0.00005493933,0.00005639075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002304327,0.0001831301,0.06174294,0.00003462739,0.00005434054,0.00005321287,0.0004021275,0.0002344077,0.8206033,0.1090244,0.004813751,0.0005493982],"study_design_scores_gemma":[0.004519993,0.0002859392,0.2772273,0.0002004587,0.00003030819,9.375026e-7,0.001705559,0.0003017001,0.009671845,0.0005972333,0.7051931,0.0002656147],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515183,0.01908433,0.006966539,0.01013497,0.006409137,0.000967819,0.000004349741,0.00004298753,0.004871586],"genre_scores_gemma":[0.9961476,0.001419361,0.0001643967,0.0003681852,0.0008162422,0.00009612922,0.000001930133,0.00001063869,0.0009755725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8109315,"threshold_uncertainty_score":0.3817191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063637651061441,"score_gpt":0.2716599583227768,"score_spread":0.2610235818121624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}