{"id":"W4412703250","doi":"10.1007/s13555-025-01484-1","title":"Clinically Meaningful Improvements in Adolescents with Moderate-to-Severe Atopic Dermatitis Treated with Tralokinumab who did not Achieve Clear or Almost Clear Skin at Week 16","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Genentech; LEO Pharma; Bausch Health; Glenmark Pharmaceuticals; Sanofi Genzyme; Incyte; CTI Biopharma; BioCryst; UCB Pharma; Sun Pharma; Regeneron Pharmaceuticals; Daiichi Sankyo Europe; Sanofi; Celldex Therapeutics; Amgen; Pfizer; Galderma; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Atopic dermatitis; Dermatology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009421626,0.0004031368,0.0009263316,0.0002467902,0.000250198,0.0000321108,0.0001792184,0.0003467609,0.00009392318],"category_scores_gemma":[0.00003143146,0.0002742407,0.0000763005,0.0003598965,0.0003152864,0.0001444697,0.00006875832,0.000402071,0.0000367575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006708962,"about_ca_system_score_gemma":0.0001785706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007489814,"about_ca_topic_score_gemma":0.0004374284,"domain_scores_codex":[0.9977674,0.0002565583,0.0006011061,0.0006174484,0.0001917645,0.0005657339],"domain_scores_gemma":[0.9990086,0.0001045589,0.0001398982,0.0004099675,0.00009420082,0.0002427739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0522742,0.0009293854,0.9343148,0.0002735292,0.000463831,0.001882526,0.0006906943,0.000009609584,0.00004328027,0.0001251367,0.002409273,0.006583693],"study_design_scores_gemma":[0.03368886,0.002112959,0.9497095,0.001581819,0.0001917722,0.003504958,0.0003883869,0.0003962007,0.004113286,0.0002600962,0.003478466,0.0005736782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930014,0.0005171018,0.0001269638,0.00382574,0.00006070992,0.001017801,0.00001934559,0.00009623673,0.001334728],"genre_scores_gemma":[0.9793592,0.000674314,0.0001146866,0.01886565,0.00001605568,0.0001019399,0.00004446164,0.00004159091,0.0007820901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01858534,"threshold_uncertainty_score":0.999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293161049824988,"score_gpt":0.2713952044670975,"score_spread":0.2584635939688476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}