{"id":"W4412704108","doi":"10.1016/j.cgh.2025.07.028","title":"Upadacitinib Maintenance Therapy in Crohn’s Disease: Final Results From the Randomized Phase 3 U-ENDURE Study","year":2025,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Medicine; Crohn's disease; Maintenance therapy; Internal medicine; Crohn disease; Randomized controlled trial; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005019695,0.0009492483,0.002610083,0.0002622928,0.0003967572,0.001069965,0.000840947,0.001320665,0.003581545],"category_scores_gemma":[0.003046004,0.0003874072,0.00249179,0.0003570278,0.0005999468,0.0007833402,0.0005397795,0.001952384,0.0005200367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004786215,"about_ca_system_score_gemma":0.00089146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004178153,"about_ca_topic_score_gemma":0.001532098,"domain_scores_codex":[0.9983942,0.001066435,0.0000827457,0.0001330498,0.0001589861,0.0001645319],"domain_scores_gemma":[0.9980513,0.0005241731,0.0005622279,0.0002289807,0.000170532,0.0004628027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9394798,0.005367988,0.003778163,0.0007827926,0.003271447,0.00012888,0.00007938979,0.0005518993,0.004636738,0.0001132681,0.003842974,0.03796659],"study_design_scores_gemma":[0.8693327,0.09904131,0.02246096,0.0001463478,0.003039619,0.0002852729,0.00004298988,0.0007726559,0.001736983,0.0002139754,0.002882797,0.00004446743],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741129,0.01365367,0.001410477,0.0009238365,0.0002431911,0.003593458,0.003297693,0.0002226298,0.002542115],"genre_scores_gemma":[0.9821411,0.003230559,0.00270353,0.001492531,0.0002686828,0.003102473,0.005326482,0.00005473146,0.001679909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005019695,"threshold_uncertainty_score":0.02654701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02873792952206333,"score_gpt":0.3458846376330007,"score_spread":0.3171467081109374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}