{"id":"W4412707981","doi":"10.1038/s41467-025-60410-3","title":"Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation","year":2025,"lang":"en","type":"review","venue":"Nature Communications","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Novo Nordisk Fonden; Novo Nordisk; European Commission","keywords":"Machine perfusion; Economic shortage; Medicine; Kidney transplantation; Dialysis; Intensive care medicine; Limiting; Transplantation; Kidney; Kidney disease; Organ transplantation; Perfusion; Surgery; Internal medicine; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002899206,0.0004864047,0.001140386,0.00144089,0.0003113865,0.001855797,0.00102837,0.001581036,0.002734128],"category_scores_gemma":[0.003418114,0.0001992547,0.0008330711,0.001624371,0.0007797464,0.002520707,0.001038652,0.002420735,0.001066654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007584293,"about_ca_system_score_gemma":0.002483865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001297076,"about_ca_topic_score_gemma":0.002013577,"domain_scores_codex":[0.9991676,0.0002628427,0.0001407413,0.00008799459,0.0002686363,0.00007229876],"domain_scores_gemma":[0.9979967,0.001258742,0.0002097911,0.00004942877,0.0004110314,0.00007425072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005723098,0.00004675272,0.0001769469,0.02410622,0.00008120815,0.0001295499,0.0001188966,0.0003790586,0.0004889813,0.009590787,0.019135,0.9456894],"study_design_scores_gemma":[0.00001792479,0.0001379502,0.0008236761,0.01741306,0.000155707,0.0008405642,0.0002109074,0.0001559815,0.0003860247,0.005312557,0.9745172,0.00002845057],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000986791,0.997597,0.0001565479,0.001099556,0.0002768981,0.000003219904,0.000007555184,0.000005144774,0.0007553995],"genre_scores_gemma":[0.001072096,0.9976873,0.0002653305,0.0004549616,0.0003060373,0.000006441396,0.00001315494,0.000002258356,0.0001924964],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002899206,"threshold_uncertainty_score":0.01533264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0624019408868489,"score_gpt":0.3805192561650951,"score_spread":0.3181173152782462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}