{"id":"W4412725626","doi":"10.1002/bit.70031","title":"Exploring Multi‐Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far","year":2025,"lang":"en","type":"review","venue":"Biotechnology and Bioengineering","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Providence Health Care","keywords":"Crosstalk; Organ-on-a-chip; Computational biology; Biology; Organ system; Preclinical testing; Neuroscience; Computer science; Bioinformatics; Nanotechnology; Medicine; Pathology; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001941234,0.0008729346,0.001212957,0.0009582844,0.0003128305,0.002163171,0.001219983,0.001509652,0.00314382],"category_scores_gemma":[0.0016343,0.0004090273,0.001100854,0.0006544661,0.000967343,0.002222095,0.0009996206,0.002701897,0.001451998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005539252,"about_ca_system_score_gemma":0.001040832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011425,"about_ca_topic_score_gemma":0.00135966,"domain_scores_codex":[0.9993357,0.0001446641,0.00004784084,0.0001445466,0.0002586071,0.00006855134],"domain_scores_gemma":[0.9987071,0.0006354403,0.00007389158,0.00008059317,0.0003878942,0.0001150658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003896226,0.0002831189,0.002784251,0.01564844,0.0002727607,0.00137786,0.0008998226,0.004003014,0.114282,0.02523265,0.03496267,0.7998638],"study_design_scores_gemma":[0.00003235237,0.001170085,0.002704957,0.00145837,0.0003144358,0.003194216,0.00068086,0.004255659,0.0903521,0.01013613,0.8855236,0.0001773152],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01525157,0.9027828,0.05875817,0.005872928,0.002113061,0.0001157667,0.0004024652,0.0007307311,0.01397247],"genre_scores_gemma":[0.06217776,0.8757997,0.04488336,0.004407685,0.001716751,0.0002536161,0.0009133929,0.000237838,0.009609927],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00314382,"threshold_uncertainty_score":0.01051712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1021323429533863,"score_gpt":0.3238791290788763,"score_spread":0.22174678612549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}