{"id":"W4412726366","doi":"10.1016/j.jbc.2025.110522","title":"Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science","keywords":"Exon; RNA splicing; Intron; Alternative splicing; Biology; Splice site mutation; Exon shuffling; Exon skipping; Cell biology; Splicing factor; Exonic splicing enhancer; Precursor mRNA; Genetics; RNA-binding protein; Tandem exon duplication; Messenger RNA; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002256118,0.0004033969,0.0002403688,0.0001810873,0.000187401,0.0002156714,0.000435204,0.0003518806,0.0006552596],"category_scores_gemma":[0.0002528045,0.0001587947,0.0004118999,0.00005165768,0.0003072558,0.000236232,0.0002056277,0.0003793099,0.0005616016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003312695,"about_ca_system_score_gemma":0.0002704098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000455693,"about_ca_topic_score_gemma":0.000349313,"domain_scores_codex":[0.9998036,0.00002995502,0.00001382258,0.00006144408,0.00004818356,0.00004303818],"domain_scores_gemma":[0.9998011,0.00003253285,0.00005704925,0.00002259674,0.00003276838,0.00005393866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006083625,0.00001636124,0.0004427361,0.00002221313,0.000003497387,0.0003410823,0.00001656509,0.0001756093,0.997269,0.0005367846,0.00003744054,0.001077932],"study_design_scores_gemma":[0.00004092767,0.0004835973,0.01217312,0.00001630327,0.00001970964,0.001670737,0.00005794002,0.01328838,0.9675122,0.001096634,0.003613509,0.00002688093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806126,0.001995374,0.01470537,0.0001897438,0.00006918162,0.00005639626,0.0001463729,0.000224364,0.002000625],"genre_scores_gemma":[0.9946389,0.0004235767,0.003616318,0.00006403303,0.00001659525,0.0000311174,0.0002254053,0.00001377369,0.0009703358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006552596,"threshold_uncertainty_score":0.002403498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155537035793445,"score_gpt":0.2542872302072163,"score_spread":0.2427318598492819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}