{"id":"W4412726432","doi":"10.1038/s41598-025-13411-7","title":"Genetic and computational analysis of AKR1C4 gene rs17134592 polymorphism in breast cancer among the Bangladeshi population","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Breast cancer; Genotyping; Genotype; Oncology; Population; Biology; Internal medicine; Risk factors for breast cancer; Bioinformatics; Medicine; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006829203,0.0003825847,0.0007797558,0.0007417006,0.0006092329,0.0005854481,0.000788754,0.0006203035,0.004678082],"category_scores_gemma":[0.002263055,0.0002667262,0.001234195,0.0009884994,0.0002530502,0.0002630253,0.0003791302,0.0004049935,0.0004585932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004828278,"about_ca_system_score_gemma":0.0009149493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03430863,"about_ca_topic_score_gemma":0.01875929,"domain_scores_codex":[0.9997117,0.0001200176,0.00002331613,0.00007556401,0.00003265358,0.00003663311],"domain_scores_gemma":[0.9993669,0.0004125523,0.00005476025,0.00005912915,0.00005037818,0.00005620221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002166369,0.0004976253,0.5678659,0.000399199,0.002193872,0.003943522,0.0004731798,0.3862952,0.006485411,0.004011739,0.00416661,0.02150135],"study_design_scores_gemma":[0.0003827113,0.0003828491,0.192454,0.00006344589,0.0007885679,0.0009346105,0.0006479327,0.7972127,0.0008058098,0.003870727,0.002349265,0.0001073447],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941044,0.000254068,0.002213624,0.0003411394,0.00001701646,0.00002170057,0.001743276,0.00006304922,0.001241546],"genre_scores_gemma":[0.9953307,0.0002130778,0.001999959,0.00006573138,0.00001115599,0.00004318357,0.00169249,0.00001883236,0.000624891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03430863,"threshold_uncertainty_score":0.06821781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004798127398800011,"score_gpt":0.2434015164870296,"score_spread":0.2386033890882296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}