{"id":"W4412727529","doi":"10.1007/s40257-025-00964-6","title":"Long-Term Safety and Efficacy of Risankizumab to Treat Moderate-to-Severe Plaque Psoriasis: Final LIMMitless Phase 3, Open-Label Extension Trial Results","year":2025,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Probity Medical Research; University of Toronto","funders":"AbbVie","keywords":"Medicine; Psoriasis Area and Severity Index; Psoriasis; Discontinuation; Adverse effect; Internal medicine; Dermatology Life Quality Index; Randomized controlled trial; Severity of illness; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009554332,0.000341086,0.002340765,0.000365702,0.0001734477,0.0000283543,0.000661622,0.0003564082,0.00004363986],"category_scores_gemma":[0.001542099,0.0002672255,0.0002559611,0.0004354996,0.0005245924,0.0001262946,0.0003030591,0.0004883174,0.00004876074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004048786,"about_ca_system_score_gemma":0.0005034899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005445444,"about_ca_topic_score_gemma":0.00002752866,"domain_scores_codex":[0.994607,0.001592643,0.00272838,0.0005491236,0.00008608732,0.0004367814],"domain_scores_gemma":[0.9944307,0.003343724,0.001248095,0.0004938747,0.0002954816,0.0001881069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5703167,0.003106238,0.001756772,0.0000178555,0.0008047708,0.0002587838,0.0002104247,0.00002460333,0.0009126122,0.0001673123,0.003524691,0.4188993],"study_design_scores_gemma":[0.8717362,0.03080975,0.06404888,0.0008330743,0.002319639,0.003234872,0.0003992503,0.00002208215,0.01266008,0.0001928912,0.0129144,0.0008289141],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912196,0.001036242,0.001081995,0.003736325,0.001706986,0.000672035,0.000120921,0.0000159182,0.0004099254],"genre_scores_gemma":[0.9965456,0.0009457966,0.0009194133,0.0009249551,0.000108108,0.00001345308,0.0000447264,0.00001992872,0.0004780487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4180703,"threshold_uncertainty_score":0.999978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07167977802277621,"score_gpt":0.4016706240009211,"score_spread":0.3299908459781449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}