{"id":"W4412733242","doi":"10.1101/2025.07.28.667132","title":"Impact of Inactivation Methods on Biosafety and Antigen Reactivity of <i>Brucella melitensis</i> from the Perspective of Astral-DIA Proteomics Based on Antibody Immunoprecipitation Mass Spectrometry","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Chinese Academy of Agricultural Sciences","keywords":"Brucella melitensis; Brucella; Immunoprecipitation; Biosafety; Antigen; Chemistry; Virology; Antibody; Brucellosis; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003257363,0.0004090819,0.0002128874,0.0002196547,0.0001387425,0.0004423909,0.0001930916,0.0002004302,0.000519951],"category_scores_gemma":[0.0001705654,0.0001114261,0.0003008013,0.0001731128,0.0001931645,0.0002128041,0.0001515815,0.0002693697,0.0002092694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053637,"about_ca_system_score_gemma":0.000108215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008062992,"about_ca_topic_score_gemma":0.0009543329,"domain_scores_codex":[0.9997795,0.00003679729,0.00001704541,0.00004857188,0.0000759076,0.00004213061],"domain_scores_gemma":[0.9998769,0.00002210019,0.00004833464,0.00001166016,0.00003274137,0.000008248825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005965054,0.0000121299,0.001102335,0.00003493803,0.000009608792,0.00001325979,0.000009172989,0.00002969816,0.9976545,0.00001057207,0.00002001762,0.001044137],"study_design_scores_gemma":[0.000003112538,0.0003208087,0.04150945,0.000009348908,0.0000456729,0.0001494505,0.00005235705,0.0007755689,0.956144,0.0000260251,0.0009559685,0.000008261972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953862,0.00120095,0.002161676,0.00007734808,0.00001864046,0.00002258494,0.0003690639,0.00004462183,0.0007189075],"genre_scores_gemma":[0.9949229,0.0008315111,0.002525011,0.0001086591,0.00001029988,0.00002645708,0.0007541744,0.00002163243,0.0007993419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008062992,"threshold_uncertainty_score":0.001739442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03728253987866861,"score_gpt":0.3562679876213851,"score_spread":0.3189854477427165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}