{"id":"W4412736158","doi":"10.1016/j.omtn.2025.102645","title":"mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Faculty of Tropical Medicine, Mahidol University; National Institutes of Health; Walter Reed Army Institute of Research; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Circumsporozoite protein; Virology; Malaria vaccine; Plasmodium vivax; Immunogenicity; Biology; Malaria; Plasmodium falciparum; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009820292,0.0003104317,0.000199942,0.0001162105,0.00006637119,0.000126643,0.00009781758,0.0002358357,0.0005362549],"category_scores_gemma":[0.00008013751,0.00009542893,0.0001171516,0.00007393911,0.0001420464,0.0001452414,0.00008045535,0.0003995918,0.0001430021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243428,"about_ca_system_score_gemma":0.0001179219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002222584,"about_ca_topic_score_gemma":0.0003114337,"domain_scores_codex":[0.9999236,0.00001426537,0.000004142524,0.00001879187,0.00002297498,0.00001618185],"domain_scores_gemma":[0.9999634,0.000006317509,0.0000144764,0.000003306634,0.000005928929,0.000006536611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005195368,0.00003020157,0.00004136105,0.00002437483,0.000002318632,0.00001275672,0.000004238688,0.00009490826,0.998425,0.00003548726,0.00001750452,0.001259914],"study_design_scores_gemma":[0.00002493945,0.002110892,0.001550947,0.000006602166,0.00001931016,0.0001642447,0.00001154775,0.001272725,0.9928353,0.00003978697,0.001959495,0.000004077119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923249,0.0008555211,0.005306287,0.00007758525,0.00002306343,0.00004140477,0.0001241891,0.00006993266,0.00117719],"genre_scores_gemma":[0.9928604,0.001071994,0.004000793,0.00004145114,0.00001147882,0.00005278585,0.0002771206,0.00001310602,0.001670836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005362549,"threshold_uncertainty_score":0.001793981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01519029470630217,"score_gpt":0.2744072053278249,"score_spread":0.2592169106215227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}