{"id":"W4412736158","doi":"10.1016/j.omtn.2025.102645","title":"mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Faculty of Tropical Medicine, Mahidol University; National Institutes of Health; Walter Reed Army Institute of Research; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Circumsporozoite protein; Virology; Malaria vaccine; Plasmodium vivax; Immunogenicity; Biology; Malaria; Plasmodium falciparum; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006187746,0.000234222,0.0004165102,0.0002361254,0.0001398281,0.0000436522,0.0002137181,0.0001592747,0.00008256124],"category_scores_gemma":[0.0001380534,0.0001757144,0.0001266308,0.0003667174,0.0001268899,0.00008121801,0.0000920228,0.0005414632,0.00001579072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001314958,"about_ca_system_score_gemma":0.00008833138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000412831,"about_ca_topic_score_gemma":0.0000190241,"domain_scores_codex":[0.9981205,0.0003096981,0.0004036869,0.0004306424,0.0002119242,0.000523576],"domain_scores_gemma":[0.9993367,0.00001764629,0.00008173453,0.0003842779,0.00007984678,0.00009979022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001629015,0.00007966284,0.005072978,0.0000628781,0.0001740357,0.00009163305,0.0002080688,0.00000381004,0.9740314,0.000264155,0.0002131287,0.01816927],"study_design_scores_gemma":[0.0207193,0.003920041,0.1910022,0.001189577,0.0000932727,0.0004242319,0.0006959889,0.002335282,0.7302821,0.003343919,0.04536033,0.0006337595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764951,0.002303002,0.001400649,0.01743047,0.00008459513,0.001717511,0.000005441705,0.00005271163,0.00051046],"genre_scores_gemma":[0.994136,0.0008746652,0.0002740024,0.003958014,0.00004359929,0.000239609,0.00001082393,0.00003050915,0.0004328271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2437492,"threshold_uncertainty_score":0.7165427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01519029470630217,"score_gpt":0.2744072053278249,"score_spread":0.2592169106215227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}