{"id":"W4412746936","doi":"10.1182/blood.2024028205","title":"Final analysis of the RESONATE-2 study: up to 10 years of follow-up of first-line ibrutinib treatment for CLL/SLL","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"Incyte; Pharmacyclics; BeiGene; TG Therapeutics; Gilead Sciences; Genentech; AstraZeneca; Eli Lilly and Company","keywords":"Ibrutinib; Chlorambucil; Medicine; Internal medicine; Chronic lymphocytic leukemia; IGHV@; Peripheral edema; Nausea; Neutropenia; Gastroenterology; Adverse effect; Oncology; Surgery; Leukemia; Toxicity; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01226678,0.001718461,0.003739126,0.0007373889,0.0007190453,0.002175385,0.001492758,0.002118337,0.002229809],"category_scores_gemma":[0.005757241,0.0006899136,0.008750619,0.0007283693,0.0006632952,0.001276407,0.001170374,0.00302133,0.0006030035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001288054,"about_ca_system_score_gemma":0.001526794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001653398,"about_ca_topic_score_gemma":0.003557058,"domain_scores_codex":[0.995112,0.002930812,0.0002737525,0.0006334808,0.000546403,0.0005035079],"domain_scores_gemma":[0.993705,0.00197197,0.001648703,0.0009615623,0.0007236975,0.0009891395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8029874,0.003100544,0.08943293,0.001762983,0.04586649,0.0005968794,0.0002581171,0.003768099,0.008059587,0.0002226879,0.007275483,0.03666876],"study_design_scores_gemma":[0.226192,0.185285,0.5111706,0.0004327675,0.05134316,0.001041502,0.0002247329,0.003380648,0.005078092,0.0006183892,0.01500158,0.0002314311],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682686,0.01020849,0.001874055,0.0006403548,0.0002511354,0.001272514,0.01456497,0.0001226963,0.002797032],"genre_scores_gemma":[0.9726411,0.0009422363,0.001088873,0.0008395431,0.0001587046,0.0009190135,0.02150446,0.00005124489,0.001854812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226678,"threshold_uncertainty_score":0.06487375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04988792393192714,"score_gpt":0.3568477804765986,"score_spread":0.3069598565446714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}