{"id":"W4412746936","doi":"10.1182/blood.2024028205","title":"Final analysis of the RESONATE-2 study: up to 10 years of follow-up of first-line ibrutinib treatment for CLL/SLL","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"Incyte; Pharmacyclics; BeiGene; TG Therapeutics; Gilead Sciences; Genentech; AstraZeneca; Eli Lilly and Company","keywords":"Ibrutinib; Chlorambucil; Medicine; Internal medicine; Chronic lymphocytic leukemia; IGHV@; Peripheral edema; Nausea; Neutropenia; Gastroenterology; Adverse effect; Oncology; Surgery; Leukemia; Toxicity; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003561787,0.0001209329,0.0006680741,0.0003419636,0.00003276635,0.000003653788,0.0002399652,0.00006819621,0.0001066422],"category_scores_gemma":[0.0005994634,0.00008499892,0.0004147135,0.001403159,0.00007757459,0.0000120199,0.0001378848,0.00005274862,0.000002554037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008841399,"about_ca_system_score_gemma":0.001976109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485987,"about_ca_topic_score_gemma":0.00160579,"domain_scores_codex":[0.9985254,0.00005225978,0.0004891818,0.0002652612,0.0004412082,0.0002266322],"domain_scores_gemma":[0.9983169,0.000439691,0.0001289209,0.000787623,0.0002608164,0.00006599568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.0539706,0.06679656,0.4865974,0.005870264,0.1348364,0.0002695625,0.04341817,0.003298609,0.0259983,0.002051455,0.02197284,0.1549199],"study_design_scores_gemma":[0.3926066,0.01316396,0.2385961,0.0009359337,0.04330678,0.0000106549,0.003188012,0.008476017,0.2729638,0.0001495648,0.0261877,0.0004148801],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973241,0.0003096488,0.00002451493,0.0003435777,0.00007594725,0.00134563,0.0001144884,0.000008805977,0.0004532799],"genre_scores_gemma":[0.9892482,0.00003703971,0.0001857383,0.00002695863,0.00002599557,0.00009069523,0.00001793314,0.00001231767,0.01035509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.338636,"threshold_uncertainty_score":0.3505532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04988792393192714,"score_gpt":0.3568477804765986,"score_spread":0.3069598565446714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}