{"id":"W4412750694","doi":"10.1007/s00018-025-05816-4","title":"REGγ regulates antiviral response by activating TBK1-IFNβ signaling through degradation of PPP2CB","year":2025,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; York University","keywords":"TANK-binding kinase 1; Degradation (telecommunications); Cell biology; Chemistry; Signal transduction; Biology; Computer science; Telecommunications; Protein kinase B","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002337098,0.0005420111,0.0002730263,0.0002526519,0.0001643131,0.0004769569,0.0001423551,0.0001787361,0.001114466],"category_scores_gemma":[0.00009255907,0.0001515396,0.0003818885,0.0001302289,0.0003091959,0.0002307356,0.0003076281,0.0003886544,0.0004094138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274316,"about_ca_system_score_gemma":0.000294011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003572905,"about_ca_topic_score_gemma":0.000594346,"domain_scores_codex":[0.9998336,0.00003407522,0.00001250453,0.00004050687,0.00002856264,0.00005065667],"domain_scores_gemma":[0.999934,0.000004508187,0.00002573269,0.000009966506,0.00001034544,0.00001540544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516241,0.000008373636,0.0005711699,0.0000540299,0.000009892738,0.0000998611,0.00001564325,0.0001116913,0.996887,0.0002212049,0.00004798883,0.001821428],"study_design_scores_gemma":[0.00001826657,0.0001448073,0.01073115,0.00001231044,0.00003391232,0.0005287309,0.00005796529,0.0007666798,0.9827316,0.0002621734,0.004705891,0.00000649556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660622,0.01584171,0.01176166,0.0002872717,0.00007701038,0.00004466959,0.0007815351,0.000281689,0.004862226],"genre_scores_gemma":[0.9938111,0.002672668,0.001462597,0.00004938378,0.00001330788,0.00001456362,0.0002554491,0.00001791404,0.001703086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114466,"threshold_uncertainty_score":0.003728211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151443330410426,"score_gpt":0.2581587908083767,"score_spread":0.2466443575042725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}