{"id":"W4412754547","doi":"10.1016/j.tmrv.2025.150913","title":"Four-Factor Prothrombin Complex Concentrate is Superior to Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery—The FARES-II (LEX-211) Phase 3, Multicentre, Randomized, Clinical Trial","year":2025,"lang":"en","type":"article","venue":"Transfusion Medicine Reviews","topic":"Trauma, Hemostasis, Coagulopathy, Resuscitation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre; University Health Network","funders":"","keywords":"Medicine; Prothrombin complex concentrate; PROTHROMBIN COMPLEX; Fresh frozen plasma; Randomized controlled trial; Surgery; Internal medicine; Coagulation; Warfarin; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01515187,0.0007149675,0.005688557,0.0005196121,0.0003861094,0.0000435951,0.0003743928,0.0003469058,0.0005453903],"category_scores_gemma":[0.01148085,0.0004512778,0.00148205,0.001293085,0.0005221278,0.0001482925,0.00006166156,0.0008108163,0.00004588447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002514544,"about_ca_system_score_gemma":0.0005733426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003625833,"about_ca_topic_score_gemma":0.0003586969,"domain_scores_codex":[0.9896025,0.002955934,0.004517138,0.001162303,0.000870095,0.0008920385],"domain_scores_gemma":[0.9905825,0.007060952,0.0005357442,0.0008716508,0.0004255713,0.0005236095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4498046,0.001093364,0.004443225,0.002468364,0.0003600611,0.00003289075,0.005817756,0.00000176936,0.008524525,0.0001065423,0.02334856,0.5039983],"study_design_scores_gemma":[0.7470809,0.002075989,0.002231186,0.008217312,0.002165983,0.00001160876,0.0009840436,0.002469625,0.001642486,0.00006106337,0.2324787,0.0005811956],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8870738,0.01305339,0.006406082,0.03220735,0.004268159,0.05628968,0.000186259,0.0001520145,0.0003633377],"genre_scores_gemma":[0.6559139,0.3036492,0.005206877,0.01670391,0.003780755,0.01218574,0.0007845513,0.0002956419,0.001479352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5034171,"threshold_uncertainty_score":0.9997939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1984887553956754,"score_gpt":0.4459030944766272,"score_spread":0.2474143390809518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}