{"id":"W4412757891","doi":"10.2196/69814","title":"The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Gerontology; Cognition; Intervention (counseling); Medicine; Baseline (sea); Psychology; Clinical psychology; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005753017,0.002212396,0.005950497,0.0007716733,0.0006533095,0.001450271,0.001262334,0.002703362,0.005490938],"category_scores_gemma":[0.007987473,0.0008619229,0.004765637,0.0009176649,0.001046541,0.001600879,0.001084403,0.002529047,0.0006546557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009337243,"about_ca_system_score_gemma":0.001404958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138387,"about_ca_topic_score_gemma":0.001595348,"domain_scores_codex":[0.9967492,0.001752889,0.0004237187,0.0005189094,0.0002685382,0.0002868058],"domain_scores_gemma":[0.9968804,0.00127671,0.0008462507,0.0002523205,0.0002771865,0.0004672063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9732323,0.005028648,0.001780326,0.002655887,0.006598822,0.00002269148,0.00005657896,0.0002021548,0.0005878488,0.000112968,0.0003483058,0.009373497],"study_design_scores_gemma":[0.9612571,0.02829334,0.004341241,0.0001994403,0.004920918,0.0000134984,0.00002592365,0.0002255608,0.0001893276,0.0001570668,0.0003597368,0.00001699393],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9348791,0.02459889,0.002511345,0.001482513,0.0008305768,0.02858557,0.002606354,0.0001674721,0.00433811],"genre_scores_gemma":[0.9271172,0.00624756,0.005675939,0.001988739,0.001264998,0.05337158,0.001489883,0.00003719485,0.002806924],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005950497,"threshold_uncertainty_score":0.03042519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718404805384081,"score_gpt":0.3987548127022978,"score_spread":0.381570764648457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}