{"id":"W4412761381","doi":"10.1021/acs.jnatprod.5c00446","title":"Value Addition to African Natural Product-Based Drug Discovery Initiatives","year":2025,"lang":"en","type":"review","venue":"Journal of Natural Products","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Natural product; Drug discovery; Value (mathematics); Product (mathematics); Traditional medicine; Chemistry; Medicine; Computer science; Biology; Stereochemistry; Mathematics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001450983,0.0007211606,0.0006454238,0.0025491,0.0005159779,0.001887003,0.0008296193,0.001365358,0.008747166],"category_scores_gemma":[0.00161643,0.0002090208,0.0005173896,0.002991788,0.0006673879,0.002211006,0.001401127,0.002141526,0.002472667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001239432,"about_ca_system_score_gemma":0.003937601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505009,"about_ca_topic_score_gemma":0.003460869,"domain_scores_codex":[0.9996467,0.00008938932,0.0000291311,0.00004434707,0.0001317934,0.00005876327],"domain_scores_gemma":[0.9991179,0.000404843,0.000118969,0.00002824157,0.0002252356,0.0001048446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005210237,0.00006640952,0.0001466787,0.02171635,0.00006324718,0.0002733663,0.0001513606,0.0002498354,0.002247711,0.02348973,0.03481634,0.9167269],"study_design_scores_gemma":[0.000005239448,0.00003524239,0.0002334668,0.003216936,0.00003547317,0.0003268916,0.00005340462,0.00002406203,0.0003475391,0.001435002,0.9942818,0.000004889775],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001573391,0.9942905,0.0001777221,0.001326268,0.0004501553,0.000007208573,0.00002035684,0.000008863094,0.003561646],"genre_scores_gemma":[0.001802322,0.9952088,0.000339768,0.0007564941,0.0002565329,0.000007370207,0.00003123864,0.000002734787,0.001594704],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008747166,"threshold_uncertainty_score":0.02926219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916096028994558,"score_gpt":0.3265703583188325,"score_spread":0.3074093980288869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}