{"id":"W4412761381","doi":"10.1021/acs.jnatprod.5c00446","title":"Value Addition to African Natural Product-Based Drug Discovery Initiatives","year":2025,"lang":"en","type":"review","venue":"Journal of Natural Products","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Natural product; Drug discovery; Value (mathematics); Product (mathematics); Traditional medicine; Chemistry; Medicine; Computer science; Biology; Stereochemistry; Mathematics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009598316,0.0004918627,0.001149256,0.0005817823,0.0001082059,0.0001499035,0.0009084363,0.0002244406,0.000006141689],"category_scores_gemma":[0.005479188,0.0003262876,0.0005738912,0.0007483476,0.0001957174,0.00003976312,0.0003086613,0.001077463,0.00001352726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287956,"about_ca_system_score_gemma":0.002502352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000295405,"about_ca_topic_score_gemma":0.000004165548,"domain_scores_codex":[0.9966414,0.0003388698,0.001155014,0.0005119322,0.0008466111,0.0005061859],"domain_scores_gemma":[0.9973089,0.0001283104,0.0008601637,0.0005590587,0.000932503,0.0002111117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002700029,0.0002294702,0.000001345708,0.01900851,0.0005166892,0.00003349067,0.00008044477,0.000007610563,0.002225917,0.00002542237,0.1157258,0.8618753],"study_design_scores_gemma":[0.0003341534,0.0004332057,0.00002461114,0.005979445,0.000268758,0.00006766727,0.00004864292,0.00000451943,0.008307402,0.00002102712,0.9840758,0.0004347435],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002751058,0.9940756,0.00005188535,0.001525051,0.002700502,0.0009141229,0.0001630791,0.000007780904,0.0002868949],"genre_scores_gemma":[0.008748034,0.9805683,0.002678335,0.000381982,0.003295013,0.0000208083,0.0007080873,0.00003808529,0.003561352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.86835,"threshold_uncertainty_score":0.9999189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916096028994558,"score_gpt":0.3265703583188325,"score_spread":0.3074093980288869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}