{"id":"W4412768541","doi":"10.1021/acscatal.5c03488","title":"Investigating the Substrate Specificity of l-Rhamnose Biosynthetic Enzymes (RmlA–D): Chemoenzymatic Synthesis of an Isosteric Nonhydrolyzable TDP-β-l-Rhamnose Phosphonate","year":2025,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts","keywords":"Phosphonate; Enzyme; Stereochemistry; Chemistry; Rhamnose; Substrate (aquarium); Catalysis; Biosynthesis; Substrate specificity; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002116106,0.0002807308,0.0001443832,0.00006607079,0.00006562252,0.0002472569,0.0001573776,0.0002562228,0.000449376],"category_scores_gemma":[0.0002188908,0.00009494559,0.0001244633,0.0001087765,0.0001634366,0.0002258083,0.000169665,0.0003920709,0.000287809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304689,"about_ca_system_score_gemma":0.0002051496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007319985,"about_ca_topic_score_gemma":0.0008096459,"domain_scores_codex":[0.9998549,0.00002625647,0.00001197423,0.0000388418,0.00003288062,0.00003509807],"domain_scores_gemma":[0.9998938,0.00002833956,0.00003381724,0.00001180916,0.00001802283,0.00001416283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002247932,0.000008243191,0.0000711598,0.00002043477,0.000001308693,0.00001457493,0.00001024797,0.00007923572,0.9989672,0.00004926393,0.00000874997,0.00074713],"study_design_scores_gemma":[9.553333e-7,0.00004838145,0.0002190802,8.884074e-7,0.000001312772,0.00002811972,0.00000579944,0.0002521269,0.999097,0.00000589296,0.0003388285,0.000001606031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927593,0.0005472539,0.00459774,0.00006988331,0.000006731931,0.00002528817,0.0001451554,0.00004787877,0.001800805],"genre_scores_gemma":[0.9950641,0.0004009958,0.003652449,0.0000250658,0.000002703443,0.00001336807,0.0001362633,0.00001378348,0.0006912206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007319985,"threshold_uncertainty_score":0.001672208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153242566728546,"score_gpt":0.2230577453552177,"score_spread":0.2115253196879323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}