{"id":"W4412773643","doi":"10.21203/rs.3.rs-7153530/v1","title":"Accurate Immune Protein Structure Prediction by Large Language Model and Transfer Learning","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Natural Science Foundation of China","keywords":"Transfer of learning; Computer science; Transfer (computing); Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00125238,0.0007514181,0.00104014,0.0009195664,0.0004826569,0.001045416,0.001329798,0.00130505,0.003403293],"category_scores_gemma":[0.003984633,0.0004760995,0.001006085,0.0008538077,0.0005090514,0.002543185,0.001227452,0.00210499,0.002288148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006111754,"about_ca_system_score_gemma":0.0009474921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002986238,"about_ca_topic_score_gemma":0.003498275,"domain_scores_codex":[0.9994339,0.00020186,0.0000267454,0.0001400448,0.0001321628,0.00006530673],"domain_scores_gemma":[0.9980041,0.001228347,0.0000945707,0.0003515838,0.0002578041,0.00006355943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005913723,0.0004038707,0.002365936,0.0002263494,0.0002270125,0.0003537389,0.00007217077,0.4887578,0.01692508,0.01282927,0.01932758,0.4579199],"study_design_scores_gemma":[0.000007271754,0.00001326691,0.00009074619,0.000001935603,0.000005488584,0.00001243195,0.000003829677,0.9914201,0.001395843,0.006832892,0.0002128645,0.000003249646],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0680825,0.0007426684,0.9201038,0.000930713,0.0001714774,0.00005994645,0.0006798577,0.007113317,0.002115668],"genre_scores_gemma":[0.7609043,0.0004265874,0.22632,0.0003965075,0.0002419246,0.0001490919,0.002771135,0.0005341886,0.008256272],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003403293,"threshold_uncertainty_score":0.0113852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182923190958283,"score_gpt":0.3174155611864151,"score_spread":0.2991232420905868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}