{"id":"W4412785313","doi":"10.1039/d5md00375j","title":"Amphiphilic nebramine analogs synergize with β-lactam/β-lactamase inhibitor combinations, including cefepime–taniborbactam and meropenem–xeruborbactam against metallo-β-lactamase-carrying <i>Pseudomonas aeruginosa</i>","year":2025,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cefepime; Meropenem; Pseudomonas aeruginosa; Microbiology; Lactam; Chemistry; Stereochemistry; Biology; Bacteria; Antibiotics; Imipenem; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007220206,0.0002392234,0.0001798871,0.0001002879,0.00005166448,0.0001881363,0.0001250597,0.000148077,0.00197075],"category_scores_gemma":[0.00007976104,0.00006273335,0.0001661053,0.00005388674,0.00008903787,0.0001493036,0.0001375663,0.0002690515,0.0004524513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009660814,"about_ca_system_score_gemma":0.00008405822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001577248,"about_ca_topic_score_gemma":0.0003876603,"domain_scores_codex":[0.9999505,0.00001050197,0.000004745589,0.000008426367,0.00001000974,0.00001572671],"domain_scores_gemma":[0.9999565,0.00000769207,0.00001336068,0.000003581592,0.000003807149,0.00001505608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000354147,0.00005152791,0.0001475451,0.00006755535,0.00001086533,0.00005608081,0.000006313666,0.00005492038,0.9903438,0.00009127232,0.0001438052,0.008672243],"study_design_scores_gemma":[0.0001218037,0.002666909,0.003444215,0.00001276729,0.00003998656,0.0006703431,0.00002254047,0.0006250278,0.9818591,0.0000408339,0.01048886,0.000007498848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802364,0.007112041,0.002939837,0.0001696228,0.0001004402,0.0001027978,0.0003055785,0.0002138676,0.008819358],"genre_scores_gemma":[0.994745,0.001622557,0.001389363,0.00006531434,0.0000176809,0.00002216792,0.0001959052,0.00001288023,0.00192925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197075,"threshold_uncertainty_score":0.006592751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007465842827181908,"score_gpt":0.2405395213593398,"score_spread":0.2330736785321579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}