{"id":"W4412785313","doi":"10.1039/d5md00375j","title":"Amphiphilic nebramine analogs synergize with β-lactam/β-lactamase inhibitor combinations, including cefepime–taniborbactam and meropenem–xeruborbactam against metallo-β-lactamase-carrying <i>Pseudomonas aeruginosa</i>","year":2025,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cefepime; Meropenem; Pseudomonas aeruginosa; Microbiology; Lactam; Chemistry; Stereochemistry; Biology; Bacteria; Antibiotics; Imipenem; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000645299,0.0008381001,0.0008827094,0.0001551565,0.0004840393,0.0001683573,0.0006472334,0.0005424541,0.0000737196],"category_scores_gemma":[0.0006410877,0.0007568042,0.0001855077,0.0006450367,0.0008223306,0.00005616982,0.0004651124,0.0006404258,0.000006620063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835144,"about_ca_system_score_gemma":0.0005315179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005657421,"about_ca_topic_score_gemma":0.00004140998,"domain_scores_codex":[0.9960544,0.0001474867,0.0008937609,0.001369972,0.0006489922,0.0008853967],"domain_scores_gemma":[0.9974416,0.0001905362,0.0004713483,0.001079095,0.0003501217,0.0004673147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005554815,0.0002839567,0.01224926,0.0005865405,0.0004373592,0.0001226549,0.00005609546,0.00001472846,0.9809977,0.0001935079,0.00320072,0.001302011],"study_design_scores_gemma":[0.00635665,0.0003906208,0.008437561,0.001317371,0.0005909745,0.0002028695,0.0009783154,0.0001958865,0.9603744,0.0001353802,0.01960917,0.001410778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984459,0.003298747,0.000597194,0.001622068,0.0002903248,0.0005112628,0.00006363719,0.0001062335,0.009051554],"genre_scores_gemma":[0.9933987,0.001028704,0.001047086,0.001093676,0.0005177149,0.00005194121,0.0007262005,0.0001011808,0.002034806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02062326,"threshold_uncertainty_score":0.9994883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007465842827181908,"score_gpt":0.2405395213593398,"score_spread":0.2330736785321579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}