{"id":"W4412785358","doi":"10.1016/j.ebiom.2025.105841","title":"SUDEP risk is influenced by longevity genomics: a polygenic risk score study","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner","funders":"Health Research Council of New Zealand; Epilepsy Society; National Health and Medical Research Council; Cancer Research UK; Wellcome Trust; Cure Kids; National Institute for Health and Care Research; Heart of England NHS Foundation Trust; Finding A Cure for Epilepsy and Seizures; Citizens United for Research in Epilepsy; Fonds Wetenschappelijk Onderzoek; Department of Health and Social Care; Medical Research Council; Queen Elisabeth Medical Foundation","keywords":"Epilepsy; SNP; Single-nucleotide polymorphism; Disease; Medicine; Genome-wide association study; Bioinformatics; Internal medicine; Psychiatry; Biology; Gene; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006868913,0.0003022462,0.0006330569,0.0004013258,0.0002317847,0.00002352876,0.0002161398,0.0001127084,0.0005306433],"category_scores_gemma":[0.0004269715,0.0002183924,0.0001405338,0.0008569116,0.0002653105,0.00005891005,0.0001412666,0.0005663076,0.0002586934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003344061,"about_ca_system_score_gemma":0.0003207165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00416756,"about_ca_topic_score_gemma":0.0002167601,"domain_scores_codex":[0.9975953,0.000168937,0.0004758088,0.0006109989,0.0005812662,0.0005676929],"domain_scores_gemma":[0.9981849,0.0001800389,0.0001490662,0.0008993464,0.0001505719,0.0004361375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006416042,0.001486165,0.9371417,0.00006575447,0.001051332,0.0001763156,0.000809459,3.038857e-7,0.002243758,0.000004843202,0.03183775,0.02454105],"study_design_scores_gemma":[0.01273502,0.004027764,0.960638,0.0001928213,0.001074961,0.00001632829,0.0008454734,0.00008707852,0.002593436,0.0002093996,0.01738571,0.0001939936],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885576,0.005295205,0.000129503,0.002439867,0.0001996463,0.001788731,0.0002263772,0.0001082426,0.001254839],"genre_scores_gemma":[0.9931979,0.001423633,0.000139857,0.0009598734,0.0001881087,0.000110797,0.0001027954,0.00002707958,0.003849919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02434706,"threshold_uncertainty_score":0.8905784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197984798517277,"score_gpt":0.3212772898482585,"score_spread":0.3092974418630858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}