{"id":"W4412785358","doi":"10.1016/j.ebiom.2025.105841","title":"SUDEP risk is influenced by longevity genomics: a polygenic risk score study","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner","funders":"Health Research Council of New Zealand; Epilepsy Society; National Health and Medical Research Council; Cancer Research UK; Wellcome Trust; Cure Kids; National Institute for Health and Care Research; Heart of England NHS Foundation Trust; Finding A Cure for Epilepsy and Seizures; Citizens United for Research in Epilepsy; Fonds Wetenschappelijk Onderzoek; Department of Health and Social Care; Medical Research Council; Queen Elisabeth Medical Foundation","keywords":"Epilepsy; SNP; Single-nucleotide polymorphism; Disease; Medicine; Genome-wide association study; Bioinformatics; Internal medicine; Psychiatry; Biology; Gene; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00153482,0.0004499172,0.0003255873,0.0008157075,0.0004265236,0.0006579013,0.000287315,0.0004155851,0.001633374],"category_scores_gemma":[0.003117089,0.0001995605,0.0007191354,0.001065077,0.0002922319,0.0003150273,0.0007847755,0.0004722036,0.0001574427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627133,"about_ca_system_score_gemma":0.0001979396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003975216,"about_ca_topic_score_gemma":0.00278598,"domain_scores_codex":[0.9994215,0.0002346519,0.00005066158,0.0001689913,0.00006625481,0.00005797405],"domain_scores_gemma":[0.9983709,0.0004766241,0.000505469,0.0003021502,0.0001240613,0.0002208667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003663449,0.00002729876,0.9956148,0.000008025874,0.0004663958,0.0001966028,0.0001155348,0.0001605075,0.0006249311,0.00008586991,0.00009180817,0.00224184],"study_design_scores_gemma":[0.00001050709,0.0001031538,0.9985366,0.000003855007,0.0001392962,0.0002158392,0.00005061716,0.0006531507,0.00005096028,0.0001234038,0.0001082168,0.000004349403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992187,0.00007248044,0.0002771023,0.00002693223,0.000002890215,0.000004793139,0.0002198831,0.000003473346,0.0001737963],"genre_scores_gemma":[0.9994974,0.000029847,0.0001501749,0.000007928273,0.00000442248,0.000004521087,0.0002221516,0.000002262565,0.00008131327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003975216,"threshold_uncertainty_score":0.00811702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01197984798517277,"score_gpt":0.3212772898482585,"score_spread":0.3092974418630858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}