{"id":"W4412785718","doi":"10.1093/sleep/zsaf212","title":"Genome-wide gene by sleepiness interaction analysis for sleep apnea","year":2025,"lang":"en","type":"article","venue":"SLEEP","topic":"Obstructive Sleep Apnea Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Minority Health and Health Disparities; National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; National Eye Institute; University of North Carolina; National Institute on Aging; University of Illinois at Chicago; San Diego State University; Jackson State University; National Institute of Neurological Disorders and Stroke; Albert Einstein College of Medicine, Yeshiva University; Mississippi State Department of Health; University of Miami; U.S. Department of Health and Human Services; National Institutes of Health; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Ontario Institute for Cancer Research","keywords":"Sleep apnea; Obstructive sleep apnea; Candidate gene; Genome-wide association study; Medicine; Gene interaction; Genetics; Bioinformatics; Gene; Biology; Internal medicine; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003633541,0.0002710501,0.0006079125,0.0009595072,0.0001860731,0.00006279643,0.0002595576,0.0001642107,0.0005149976],"category_scores_gemma":[0.0007302551,0.0002604313,0.0004602012,0.001966406,0.000108495,0.0001690068,0.0001358984,0.0003187757,0.00009544798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004117065,"about_ca_system_score_gemma":0.00003748199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005662786,"about_ca_topic_score_gemma":0.00002559464,"domain_scores_codex":[0.9977785,0.0000790299,0.0004800161,0.0006648424,0.0004181439,0.0005794275],"domain_scores_gemma":[0.9981747,0.0002445573,0.000120748,0.0006871442,0.0005048728,0.0002679737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003259658,0.001596994,0.5137242,0.000816829,0.01860345,0.00006802123,0.0005547554,0.00163575,0.2642733,0.000815562,0.004470525,0.190181],"study_design_scores_gemma":[0.01299388,0.0009136304,0.43705,0.00006212486,0.01112045,0.00002743899,0.001347893,0.171874,0.1974959,0.0009538851,0.1648695,0.001291319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.556639,0.0009529044,0.428387,0.004616857,0.0008063897,0.001667603,0.0001445286,0.0001829373,0.006602772],"genre_scores_gemma":[0.9934467,0.0000172457,0.002005227,0.0008530547,0.0001904146,0.0002976782,0.0008126401,0.00004269486,0.002334319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4368077,"threshold_uncertainty_score":0.9999848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612227548841559,"score_gpt":0.3145924645533625,"score_spread":0.2984701890649469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}